 
- 积分
- 881
- 威望
- 881
- 包包
- 5504
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1、There is considerable evidence that several diverse cancers, both leukae-6 g4 e2 L: d7 T. ]0 I9 k, M: T
mias and solid tumours, are hierarchically organized and sustained
- V$ A5 k( D3 d4 O5 R4 H: `by a subpopulation of self-renewing cells that can generate the full
3 n, d3 E* z8 f0 P' \repertoire of tumour cells (both tumorigenic and non-tumorigenic * Y6 B/ H1 i" ^* |. W2 t' ~+ ]
cells)
7 I! f! g1 d: t2 @+ @9 L; Q E2、expression profiles、intertumoral heterogeneity、 oncogene addiction、 , E1 R0 D' Q8 \% l7 Z2 @0 o
survival roles、 committed progenitor cells是什么意思?
4 b; ?3 O' u0 s3、Interestingly, despite " C( u# [# D) Z1 w5 F% |
the heterogeneous nature of tumours, the histopathology and gene-* Y2 z1 j0 O4 ~4 x+ C
expression profiles of tumours arising in patients often remain relatively
4 G$ }8 V7 e2 A1 W5 p% ustable during progression from localized disease to metastatic and even 8 g; d. z6 J1 z8 C% {# t
end-stage disease3
! p! U Z& k4 x4、transgenic mouse models have shown $ w& ~0 ]8 ~8 |$ v& O2 s! D5 n
that mutant Hras targeted to the hair follicle region highly predisposed
1 F2 b& L- q( b6 D% U! v& `3 hmice to squamous carcinomas, whereas its targeting to more differ-, d( u l0 b; Z& z& e& k
entiated interfollicular or suprabasal cells resulted in papillomas with ! ?- s0 m# }4 R/ X9 _9 J, G
low malignant potential。Moreover, transformation of distinct breast , F: w0 @3 l6 _4 @+ e
epithelial cells in vitro has indicated that the target cell is an important % P/ Q7 T. O* V- U. J; y/ j
determinant of tumour phenotype4 [2 p# Z/ @' n1 Q. k2 `, d" x" [
5、Nevertheless, $ z/ s/ z# ?6 e9 |" s% b, C; \4 g
any cell in the hierarchy with proliferative capacity could serve as a cell 2 U5 U+ M, K6 `+ p$ S( |" K* d3 m
of origin in cancer, if it acquires mutations that re-instigate self-renewal ! J$ k' I7 C7 l. y5 [: O) k A
capacity and prevent differentiation to a post-mitotic state' Y& C0 G1 U* d: C7 O
有点多哈~~非常非常感谢~有些感觉上下读起来根本不连贯。云云雾雾的! |
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