成骨细胞分化和体内骨形成

botizhou

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皮搋子

真是一篇挺好的文章，可惜的是lz也没有做介绍，就这样真是明珠蒙尘。
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8 `! l' ^) Q# q+ h4 x* A4 sStrontium Enhances Osteogenic Differentiation of Mesenchymal Stem Cells and In Vivo Bone Formation by Activating Wnt/Catenin Signaling5 Y( m& B) V; F
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FAN YANG, DAZHI YANG, JIE TU, QIXIN ZHENG, LINTAO CAI, LIPING WANGa a
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6 r1 Z- D9 I* O+ B; y4 I4 \$ KResearch Center for Neural Engineering, Shenzhen Key Laboratory for Neuropsychiatric Modulation,Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China;( d! X4 U" x1 G9 A+ ^" b, b8 w2 q
Department of Orthopaedics, Union Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, China;5 P; m) o. K) F4 L8 D- W- `  G; T( \' U
Shenzhen Key Laboratory for Cancer Nanotechnology, Shenzhen Institutes of Advanced Technology,8 V9 D/ v7 T/ b3 @$ {5 ], r# a- o5 n, I
Chinese Academy of Sciences, Shenzhen, China
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    Strontium ranelate is a newly approved drug that can reduce the risk of vertebral fracture, which is attributed to its dual function in increasing the bone formation and decreasing the bone resorption. Strontium-containing hydroxyapatite was also demonstrated to stimulate the, J* Z2 ?( M( H# }
osteoblast activity and inhibit the osteoclast activity.However, the molecular mechanisms of strontium underly- ing such beneficial effects were still not fully understood./ E9 q& @$ z( N
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   In this study, we investigated the effects of strontium on the osteogenic differentiation of human mesenchymal stem cells (MSCs) and its related mechanism; its osteogenic potential was also evaluated using a calvarial defect model in rats. We found that strontium could enhance
  \* s; t: t# `5 I/ z& ^, T% Dthe osteogenic differentiation of the MSCs, with upregulated extracellular matrix (ECM) gene expression and activated Wnt/b-catenin pathway. After transplanting the collagen-strontium-substituted hydroxyapatite scaffold into the bone defect region, histology and computed to mography scanning revealed that in vivo bone formation was significantly enhanced; the quantity of mature and remodeled bone substantially increased and ECM accumulated. Interestingly, strontium induced an increase of bcatenin expression in newly formed bone area. In this! Q7 C- d0 \6 P( z
study, we showed for the first time that strontium could stimulate the b-catenin expression in vitro and in vivo, which might contribute to the enhanced osteogenic differentiation of MSCs and in vivo bone formation. STEM CELLS 2011;29:981–991! T2 |  E. y. V
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lifangamanda

哈哈，花了2个包包下了！以前似乎看到过！

lifangamanda

谢谢楼主呢！