成骨细胞分化和体内骨形成

botizhou

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皮搋子

真是一篇挺好的文章，可惜的是lz也没有做介绍，就这样真是明珠蒙尘。: f, J% m# E6 v& J- L6 R% ^: \) ]& T; B

7 w+ u- E$ f0 o  ^7 F, K6 WStrontium Enhances Osteogenic Differentiation of Mesenchymal Stem Cells and In Vivo Bone Formation by Activating Wnt/Catenin Signaling- q9 o7 D" k5 E, }( r, S+ H8 D

! B! w, `# i0 q2 kFAN YANG, DAZHI YANG, JIE TU, QIXIN ZHENG, LINTAO CAI, LIPING WANGa a) M9 T, |4 p) o0 T4 g4 R; ~
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Research Center for Neural Engineering, Shenzhen Key Laboratory for Neuropsychiatric Modulation,Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China;
( A* q. F& A* J4 M  s1 U( d; ADepartment of Orthopaedics, Union Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, China;
! q" H# j9 D  a( e% DShenzhen Key Laboratory for Cancer Nanotechnology, Shenzhen Institutes of Advanced Technology,6 O6 _* _: Y6 u" {. w1 ~2 A$ a
Chinese Academy of Sciences, Shenzhen, China! z" o, a2 y* O1 b7 w( e- M
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    Strontium ranelate is a newly approved drug that can reduce the risk of vertebral fracture, which is attributed to its dual function in increasing the bone formation and decreasing the bone resorption. Strontium-containing hydroxyapatite was also demonstrated to stimulate the
( K# s/ p& {  {5 M0 josteoblast activity and inhibit the osteoclast activity.However, the molecular mechanisms of strontium underly- ing such beneficial effects were still not fully understood.
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   In this study, we investigated the effects of strontium on the osteogenic differentiation of human mesenchymal stem cells (MSCs) and its related mechanism; its osteogenic potential was also evaluated using a calvarial defect model in rats. We found that strontium could enhance
/ F# X1 X; r  D6 z) z, j" qthe osteogenic differentiation of the MSCs, with upregulated extracellular matrix (ECM) gene expression and activated Wnt/b-catenin pathway. After transplanting the collagen-strontium-substituted hydroxyapatite scaffold into the bone defect region, histology and computed to mography scanning revealed that in vivo bone formation was significantly enhanced; the quantity of mature and remodeled bone substantially increased and ECM accumulated. Interestingly, strontium induced an increase of bcatenin expression in newly formed bone area. In this
* @6 \; Y4 R( z7 S/ Nstudy, we showed for the first time that strontium could stimulate the b-catenin expression in vitro and in vivo, which might contribute to the enhanced osteogenic differentiation of MSCs and in vivo bone formation. STEM CELLS 2011;29:981–991
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lifangamanda

哈哈，花了2个包包下了！以前似乎看到过！

lifangamanda

谢谢楼主呢！