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举马里兰州干细胞研究委员会2011年资助项目三类别为例，9项由PI发起的独立研究项目；13例探索基金，资助年轻研究者或其他领域研究者，新手段、新模式、新机制项目；14位博士后资助。9 P" }( m: G, ?' B/ @
研究项目的资助也有明确的范围与目的，即可以导致一些特定难治疾病创新治疗方法的有前景项目，专门项目资助年轻研究者以及其他跨领域研究者，创新思路，培养博士后，鼓励与其他机构以及产业公司合作。0 M" v& V! P: g
$ F4 f. b* R/ b cThis year’s MSCRF awards include:
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8 c9 D! ]$ z+ [9 Investigator-Initiated Research Grants (RFA-MD-11-01) – providing up to $200,000 of direct costs per year, for up to three years, to investigators with preliminary data to support their hypotheses;2 ] z/ O( ]# B* E6 ]* a- ]
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13 Exploratory Research Grants (RFA-MD-11-02) – providing up to $100,000 of direct costs per year, for up to two years, to new stem cell researchers (young investigators and scientists from other fields), for new approaches, mechanisms or models that may differ from current thinking in the field and/or new hypotheses that have little or no preliminary data; and
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14 Post-Doctoral Fellowship Research Grants (RFA-MD-11-03) – providing up to $55,000 per year, for up to two years, including direct and indirect costs and fringe benefits, to post-doctoral fellows. " D* O7 R# R4 q1 n
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All MSCRF-funded research must be conducted in Maryland, and must involve human stem cells.
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8 o& J9 P6 K3 y" d完整资助项目人与名称如下，尤其可以看看Exploratory项目和博士后项目，对学生们或有帮助：* c X! G/ {4 N' f# v0 ]
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2011 Awardees+ W' o' l1 c9 @1 j5 W! \9 s m
. h8 i/ ~7 b8 Q A- |2 m+ ]Investigator-Initiated Grant Awardees:1 m9 I5 I* z/ ]! i& F; k
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Xu Cao# G; B% E+ W7 Z" I8 \/ m' X
Johns Hopkins University- School of Medicine' g# E% f! u8 n; l' ~* Y2 d
"Stem Cell Recruitment in Anabolic versus Antiresorptive Osteoporosis Therapy”
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Linzhao Cheng6 C" L4 L- L5 g( p$ V6 ~. a% J
Johns Hopkins University- School of Medicine ! E( [8 U# M5 C4 @
In collaboration with The California Institute for Regenerative Medicine (CIRM) & MaxCyte Inc.
' ? Y6 k8 `( ?) K% X"Red Blood Cell Production From Human IPS Cells Of Transfusion-Dependent Patients”1 e% F- L# i* D. I. N5 p
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Mihoko Kai
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Johns Hopkins University- School of Medicine, k' _5 T6 y/ O0 @3 p
"Direct Generation of Human Dopaminergic Neurons By Defined Factors”2 X' d& M; i9 D; v( p7 J3 ]
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Vassilis Koliatsos# c- O1 X4 T& s1 t* r
Johns Hopkins University- School of Medicine2 `" o! K( E3 `- R( D
In collaboration with The California Institute for Regenerative Medicine (CIRM)
) R$ Z' E7 A% }7 w0 A"Stem Cell Therapies in Animal Models of Traumatic Axonal Injury”
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Dara Kraitchman) N3 f' i' Q4 D9 D0 @. \6 t
Johns Hopkins University- School of Medicine; v! I5 S9 Z% _
In collaboration with Surgivision, Inc.. q$ c1 H9 d6 g0 ?$ A
"Single Cell Microencapsulation for Ischemic Heart Disease Therapy”: D/ m4 e( x+ I# D) F
- x- m# P& d: H% jJohn Laterra: j0 c* W1 a$ `/ d3 E l$ p1 C* R
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
' ]% p& h( J V3 l4 E1 B( c"Regulation of Neural and Neoplastic Stem Cells by Kruppel-like Transcription Factors”% T: u) S' A5 J6 U& i N
; c* G0 c( s! Y5 D6 T8 E7 [* qFeyruz Rassool
3 o7 H" B; P/ MUniversity of Maryland, Baltimore - School of Medicine
- d* L+ B1 _% ] ^0 U"Remodeling the DNA Damage Response in Induced Pluripotent Stem Cells” S4 w1 e3 H, g5 j' i2 `. y
# i" Q/ O, @6 N7 xPiotr Walczak
( E$ s5 V' s: q# D+ PJohns Hopkins University- School of Medicine
' V u+ M$ } P( D% h3 I( V. UIn collaboration with Q Therapeutics   Â
* l3 v8 h# ~8 ^, Q2 I( e; u"Intra-arterial Targeted Delivery of Stem Cells to Brain Lesions Under MRI Monitoring”
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Elias Zambidis
6 G7 [8 X d# G5 XJohns Hopkins University- School of Medicine
/ v# ^% {3 R8 BIn collaboration with Life Technologies, Inc.
( |0 z$ a4 U% v& M; t% P2 z"Clinical-Grade CD34-iPSC for Hematologic and Cardiac Therapies” * X5 B4 U y4 D$ C8 f. t6 ~
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' `" Z6 M8 n& d) \% `4 pExploratory Grant Awardees:- ]6 @# D" S) A, t( ~( R9 C) f
' |# i( _0 l6 f3 QMary Armanios
* L! M: W- T8 t2 F" pJohns Hopkins University- School of Medicine* a8 w& J( m! `
"Telomerase in Ex Vivo Expanded Hematopoietic Stem Cells”
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9 U( s7 l7 O& D" o! D; E* `; x2 g; @Visar Belegu" y% g* u2 p1 u T- {& u; J" h
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.5 S$ e* e0 H( o* s! M' S
"Differentiation of Fibroblast-Derived Induced Pluripotent Cells into Oligodendrocytes for Treatment of Neurological Disorders”
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Amy Belton4 S l4 B2 D; M* [0 F
Johns Hopkins University- School of Medicine
! m3 k; @0 W( W6 k"The Role of Hmga1 in Intestinal Stem Cells & The Generation Gut-Like Tissue”! \8 l$ e5 V' t6 p I7 x
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Robert Brodsky
) k8 ?2 ^$ V: g* `Johns Hopkins University- School of Medicine9 N+ @: @2 F3 i, ]- @
"A Preclinical Model of Acquired Aplastic Anemia Using Human iPSCs”5 ~* u% c6 S+ r
1 D2 a0 F5 Z6 H$ l1 q- A" t" DKan Cao
1 ~7 k" D; H$ y5 t& e9 E+ FUniversity of Maryland, College Park 0 f) E6 E# m6 \( F8 o. H" T
"Induced Pluripotent Stem Cells as Models of Hutchinson Gilford Progeria Syndrome”
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Raghothama Chaerkady) g f! o6 E9 L
Johns Hopkins University- School of Medicine
/ i( t8 c& g( k' b. X& x"Signaling Mechanisms Specifying Oligodendrocyte Development”
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- R# e w! s) Z+ ]! I+ S: L1 E4 H: EXiaochum Chen
o6 z( D1 [1 `4 `1 ZUniversity of Maryland, Baltimore - School of Medicine 7 ]# Q- t, `$ }: ?
"Microrna Regulators of Ex Vivo Human Hematopoietic Stem Cell Expansion”
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Stephen Desiderio7 ?+ i2 g. ^3 f* _0 W
Johns Hopkins University- School of Medicine, \' R2 x ^( @- D3 {
"Stromal Hedgehog Signaling In B Lymphoid Differentiation from Human ASCs”
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5 S3 J* T2 C g$ E" u( y% e6 ?Shao Du
; c$ W& _! z6 o. eUniversity of Maryland, Baltimore - School of Medicine
% o: ~4 M7 e, S! @, p" F9 N8 {"Reprogramming Of Satellite Cells & Human Mesenchymal Stem Cells For Muscle Repair”
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/ K1 J6 _$ f) ~+ O* f% n1 ~Koko Ishizuka
# n7 X( q1 m$ gJohns Hopkins University- School of Medicine
# O- Y$ ?% U, Z5 T* J"Alteration in Neural Fate in Schizophrenia”
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Saul Sharkis. ]- [+ O0 M r# P7 V
Johns Hopkins University- School of Medicine5 @& ]: R4 d6 ]. `4 b3 A: Y
In collaboration with Quality Biological, Inc.7 p& u4 E3 r0 g2 R; w- j2 h* Y
"Human Stem Repair of Epithelial Tissue”
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$ X8 C2 u1 m: G, PPaul Yarowsky T$ h: \" q$ t2 T: q; m8 p
University of Maryland, Baltimore - School of Medicine
+ m n/ v4 L+ R- ]"Stem Cell Therapy for Traumatic Brain Injury”
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! k) c+ _- L+ @$ A: z5 H, XZhaohui Ye v3 m6 d) ]) H4 i2 M% O. r
Johns Hopkins University- School of Medicine1 ^) z2 y- k6 T& g! @7 d; c9 t
"Clinical Drug Screening Using Patient Specific Human iPSCs”
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( N8 q) _+ L0 g! E$ K1 @: {7 `Post - Doctoral Fellowship Grant Awardees:
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Dian Arifin
5 \& V. B1 `! ~& OJohns Hopkins University- School of Medicine
3 i! H r7 V: A5 |In collaboration with Pearl Lifescience Partners, LLC / H. e& G& J- I: F+ V
"Encapsulated Human Mesenchymal Stem Cells For Improved Islet Cell Therapy”
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7 I1 { _2 I# H! GWilliam Brandt
5 P, Q2 n7 }; i* s7 c2 Z3 D* ]. ZJohns Hopkins University- School of Medicine
/ O. M, V9 K$ \2 {3 |! P$ b"Characterizing Notch Signaling in Bladder Cancer Stem Cells”7 r- e+ c) f1 a( O, {1 W
& w+ v2 ?6 Y! c* ~2 a: tNamshik Kim9 w9 }! C4 W, a, t* F5 X& X7 K
Johns Hopkins University- School of Medicine# f- X6 w2 c6 Q, f* I
"Understanding The Role Of CYFIP1 Deletion/Duplication In Schizophrenia & Autism”
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Julien Maruotti
% ?; e! k* U; A+ S" y( }4 G, d) KJohns Hopkins University- School of Medicine
9 m: n, s# C( e! K$ H) h, m( X"A High Content Screen for Small Molecules that Promote Stem Cell differentiation into Retinal Pigmented Epithelial Cells for Potential Treatment of Age-Related Macular Degeneration and Other Retinal Degenerations”- p [, p: h( ?$ {) p3 W; Z ]
5 k V) n9 \ f s: n7 V0 qTammy Morrish
0 W& a2 d2 ~* B, b8 L L* X& wJohns Hopkins University- School of Medicine1 I% l. W, q$ j4 o
"Telomere Recombination Mechanisms in Mesenchymal Stem Cells”9 n& n" `, l% F" \0 ^
$ `1 V% d% C$ @2 S, b$ Z- o! DAmanda Phillips) x+ K0 r, N' N' Q4 M1 S8 z( K& w
Johns Hopkins University- School of Medicine: b- E+ f+ I3 \! a
"Focal Transplantation of Human Neural Stem Cell-Derived Astrocytes Isolated From Als Patients into the Rat Spinal Cord”
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Prakash Rath$ N9 z- Y, p: i" \2 l' J5 U& a& t8 S$ f
Hugo W. Moser Research Institute at Kennedy Krieger, Inc. ]! F" @' U' v0 p& m: r
"Modulating HGF/c-Met Signaling in Human Normal and Neoplastic Stem Cells”
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Sandeep Shah+ X& | [- t$ O7 h: j9 I
Johns Hopkins University- School of Medicine* M- Y* e, E" Q- e+ }
In collaboration with Life Technologies, Inc. F1 Z6 Q( M$ t2 _
"HMGA Proteins in Stem Cell Survival and Induced Pluripotency”8 C8 p4 h/ b1 Y0 O% U) S
. M% B6 _5 W: dShobana Shanmugasundaram
% g* O# C5 u. ]' _( q! L( }# IUniversity of Maryland, Baltimore - School of Medicine $ ~2 g. Z3 \0 C0 [+ y
In collaboration with Biosurface Engineering Technologies, Inc.  Â
& w- n# w' z$ v7 Y/ A- v2 m"Optimization of the 3D Scaffolds with Enzyme and Peptide for Osteogenic Differentiation in Stem Cells”
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l# |# c, j! I1 u5 J8 r. [Yang Song
$ z7 l, z4 U4 d! J6 W% J( F0 y# C$ iJohns Hopkins University- School of Medicine3 U' M# i+ c: X. @& N/ _5 R2 l
In collaboration with Innovative Biosensors, Inc.4 @& V. e+ `7 P6 Q( X( n
"Signals Cooperating with RUNX1 to Specify Adult HSC from hESC”3 f# ?4 t. L- n
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Juan Song
8 b u. L! b: P/ S, EJohns Hopkins University- School of Medicine
( M1 k" s# w$ p( O, b( _2 B6 nIn collaboration with Life Technologies, Inc.
. m! O5 a# I& ?1 Y) P"Understanding the Mechanism of a Schizophrenia Susceptibility Gene Disc1 in Regulating Synapse Development Using Patient-Derived iPSCs”0 |. r) q, u6 _$ n
! @' J+ p/ g: H& d" P& z" @8 v. iYijing Su. {7 o# G) X z6 Z
Johns Hopkins University- School of Medicine
5 m+ M; y) T" C+ n+ N"Roles of Tet Proteins In Regulating DNA Demethylation And Differentiation of Human Pluripotent Stem Cells And Neural Progenitors”
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Chiaochun Joanne Wang- U3 Q, F# _" B! S! Q
Johns Hopkins University- School of Medicine
6 x) ]% p, k6 T; B5 Q4 Y$ b"Microvasculature Mimicking Microfluidics for High-Throughput Screening of Targeted and MR Trackable Stem Cells”0 _4 U0 m# X* Q: S8 o2 a
5 n9 F. {( Q) U3 B- z$ D5 I" N
Shuming Zhang
3 L; F7 h' e% x" V% q) lJohns Hopkins University- School of Medicine1 T) q1 k2 T" W7 Y/ R
"Role of Electrical Stimulation on Differentiation of Human iPS Cells and iPS-Derived Neural Crest Stem Cells” |
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发表于 2011-5-27 21:59
