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( e8 i; h* t( C5 R4 o9 H: \$ D举马里兰州干细胞研究委员会2011年资助项目三类别为例，9项由PI发起的独立研究项目；13例探索基金，资助年轻研究者或其他领域研究者，新手段、新模式、新机制项目；14位博士后资助。
! R) o! R9 v! L研究项目的资助也有明确的范围与目的，即可以导致一些特定难治疾病创新治疗方法的有前景项目，专门项目资助年轻研究者以及其他跨领域研究者，创新思路，培养博士后，鼓励与其他机构以及产业公司合作。3 s) f0 W7 W- u8 e; @4 `
1 c# `* u; d8 d( q6 Y) H9 xThis year’s MSCRF awards include:# s3 s7 S2 c) e5 C3 @+ l. ^0 G
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9 Investigator-Initiated Research Grants (RFA-MD-11-01) – providing up to $200,000 of direct costs per year, for up to three years, to investigators with preliminary data to support their hypotheses;" J) Z7 R7 k' ?# b( L- S
" d* p6 y/ T' y13 Exploratory Research Grants (RFA-MD-11-02) – providing up to $100,000 of direct costs per year, for up to two years, to new stem cell researchers (young investigators and scientists from other fields), for new approaches, mechanisms or models that may differ from current thinking in the field and/or new hypotheses that have little or no preliminary data; and
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14 Post-Doctoral Fellowship Research Grants (RFA-MD-11-03) – providing up to $55,000 per year, for up to two years, including direct and indirect costs and fringe benefits, to post-doctoral fellows.
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4 _' H2 y& q( M3 n8 fAll MSCRF-funded research must be conducted in Maryland, and must involve human stem cells.) X" U7 u; R( c% n. o
. s7 D' B7 a/ t v6 C5 W& H完整资助项目人与名称如下，尤其可以看看Exploratory项目和博士后项目，对学生们或有帮助：1 Q3 _; x" @5 x) x: U( n' r! W
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2011 Awardees
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( S7 ?7 _/ r7 ?" WInvestigator-Initiated Grant Awardees:
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- q+ G8 J# G* E' b" D- Y8 hXu Cao
4 U4 _0 W* S, ~& i. J0 m9 ^! o8 mJohns Hopkins University- School of Medicine2 C8 {+ K" ?. {4 i# r* N: P
"Stem Cell Recruitment in Anabolic versus Antiresorptive Osteoporosis Therapy”
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4 K: B7 H+ J- ~0 c$ jLinzhao Cheng: w' N5 ~4 F" i
Johns Hopkins University- School of Medicine C: M$ h y2 N1 ]1 e
In collaboration with The California Institute for Regenerative Medicine (CIRM) & MaxCyte Inc. ; k* `1 x% N$ J! u: x* o' [4 S
"Red Blood Cell Production From Human IPS Cells Of Transfusion-Dependent Patients”
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% m! n& C f8 ]0 C. Y. I# X1 I2 ZMihoko Kai
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i" {: s. I) F8 f# T8 R0 LJohns Hopkins University- School of Medicine
6 H! d2 g' Y \7 o$ e% @" K2 ?"Direct Generation of Human Dopaminergic Neurons By Defined Factors”1 _( q, l/ R6 K8 K
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Vassilis Koliatsos
% z d+ `6 B2 L+ Z0 `Johns Hopkins University- School of Medicine
2 G ~0 ~+ |5 SIn collaboration with The California Institute for Regenerative Medicine (CIRM)
, W8 m2 w8 i& M/ b"Stem Cell Therapies in Animal Models of Traumatic Axonal Injury”
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1 A# E2 O8 j5 L `- nDara Kraitchman
1 Q3 E. @5 K0 b( F3 `: L8 c2 |Johns Hopkins University- School of Medicine# V& Q' ]; E3 @5 K# q# [" n
In collaboration with Surgivision, Inc.8 @& |( {- o! s) n, M
"Single Cell Microencapsulation for Ischemic Heart Disease Therapy”
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/ H$ l" `, W; a/ [( k+ w2 c& \: o. fJohn Laterra
+ p! f4 d7 f) J* X+ e0 vHugo W. Moser Research Institute at Kennedy Krieger, Inc.
$ i& i. @: t" \- L( T- B4 U3 ?"Regulation of Neural and Neoplastic Stem Cells by Kruppel-like Transcription Factors”
1 k% E1 z B1 d* c: U& ?' j& j. z" V' q E4 s. `/ I5 k- q# @% Q$ w# h
Feyruz Rassool
2 X* M. r) K* h f |University of Maryland, Baltimore - School of Medicine
3 s+ X" t" A0 ]3 w( ~, b( Z"Remodeling the DNA Damage Response in Induced Pluripotent Stem Cells”- K. N7 O* [8 f8 [+ w
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Piotr Walczak* S. J; `. t. ~2 j% H
Johns Hopkins University- School of Medicine
. r( p9 m N6 c. D" hIn collaboration with Q Therapeutics    6 J# w( p" ^% Z3 m" z
"Intra-arterial Targeted Delivery of Stem Cells to Brain Lesions Under MRI Monitoring”$ o5 q+ ?& j5 ]1 {* j+ M
6 I! j( y: P. y' o& y8 m& gElias Zambidis
3 u5 M, K7 x. s2 j, g8 OJohns Hopkins University- School of Medicine
+ r* H6 G/ Z" z; x! f, yIn collaboration with Life Technologies, Inc.) Q8 C+ Z% E1 G( M3 z7 m" c
"Clinical-Grade CD34-iPSC for Hematologic and Cardiac Therapies” ) ], j* x* i# Q5 O( Y( o5 h/ d
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+ B0 Z/ u9 v2 Z1 h, gExploratory Grant Awardees:
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Mary Armanios * Z+ F% ]9 F! y/ s0 {. m. j
Johns Hopkins University- School of Medicine
2 Q5 ^7 V0 X0 s: }"Telomerase in Ex Vivo Expanded Hematopoietic Stem Cells”! H% ^( E) ~8 x" R
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Visar Belegu
4 `8 B4 m0 [2 o. \" rHugo W. Moser Research Institute at Kennedy Krieger, Inc.
! g9 n4 F+ b; ]7 x" ]+ g/ f% F1 u"Differentiation of Fibroblast-Derived Induced Pluripotent Cells into Oligodendrocytes for Treatment of Neurological Disorders”
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5 d3 G: k. e! w+ H; {. a) }+ y3 AAmy Belton0 }6 |! R5 T: V0 s8 ?+ b
Johns Hopkins University- School of Medicine
/ n) V! G S- _+ V% {1 {"The Role of Hmga1 in Intestinal Stem Cells & The Generation Gut-Like Tissue”9 C) a3 [( i& L8 N" S
" M7 p0 S& c8 wRobert Brodsky
8 D, p" _6 F/ E8 |4 W0 j5 e" f5 CJohns Hopkins University- School of Medicine2 o, v: A7 L6 f
"A Preclinical Model of Acquired Aplastic Anemia Using Human iPSCs”$ y6 Z+ n! a2 O4 J4 T1 T( S/ Q% E
' l+ N t: R& z+ JKan Cao) C& x0 q2 T& L, f% l
University of Maryland, College Park ) p7 d, `! z P0 f1 B( d6 J
"Induced Pluripotent Stem Cells as Models of Hutchinson Gilford Progeria Syndrome”
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( V0 }: u) R/ q, y H+ oRaghothama Chaerkady( U% T/ z- }; @
Johns Hopkins University- School of Medicine
' ?1 H3 O8 F P3 |, n"Signaling Mechanisms Specifying Oligodendrocyte Development”$ `2 o. |/ s$ A0 G
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Xiaochum Chen
2 h3 U: V/ c7 M- {* r& N0 AUniversity of Maryland, Baltimore - School of Medicine
, ^6 Y* o4 M# x4 v9 f/ Y"Microrna Regulators of Ex Vivo Human Hematopoietic Stem Cell Expansion”
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Stephen Desiderio. B4 P2 [5 F! V: v4 M
Johns Hopkins University- School of Medicine3 t$ k g& F# ~
"Stromal Hedgehog Signaling In B Lymphoid Differentiation from Human ASCs”0 A% J! y9 ]+ v' R% z# e
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Shao Du5 ?$ f9 y& e! s! _# O2 A
University of Maryland, Baltimore - School of Medicine + X0 n% }9 P P: k0 C) I
"Reprogramming Of Satellite Cells & Human Mesenchymal Stem Cells For Muscle Repair”* R$ s# K0 l8 K0 b0 g$ n& V
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Koko Ishizuka+ x, ]5 f4 Q! F, U8 n) ~9 L
Johns Hopkins University- School of Medicine: @; Y& E1 K ?( \+ z( l9 a. a/ V
"Alteration in Neural Fate in Schizophrenia”
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% P6 }: L& [. C& G$ v" SSaul Sharkis! s1 Q. T$ q' ^0 ?
Johns Hopkins University- School of Medicine
, V( O$ H. W- Q9 d2 c- X9 d9 hIn collaboration with Quality Biological, Inc.
7 U0 V- I& C2 x, Q. Q( K"Human Stem Repair of Epithelial Tissue”
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7 a" v: N6 @% w, i4 N+ dPaul Yarowsky
; [6 E4 v- ^ P7 F/ L# `University of Maryland, Baltimore - School of Medicine 3 Z. d+ J1 b# m; p* p- w3 f. \
"Stem Cell Therapy for Traumatic Brain Injury”1 Y8 |& `1 M, C% d4 U% q# u
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Zhaohui Ye3 H" g& A( N" c% f- J. L2 `
Johns Hopkins University- School of Medicine/ `$ j- L( G; M6 M, u
"Clinical Drug Screening Using Patient Specific Human iPSCs” ' w5 O! t2 Q1 Y: g' D! {% \) t/ n9 t
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Post - Doctoral Fellowship Grant Awardees:, b2 j; X- j) w
& s) U2 k n+ b/ g+ a, k, xDian Arifin
3 \. _- y* G4 NJohns Hopkins University- School of Medicine
+ I- J- X Z7 g5 bIn collaboration with Pearl Lifescience Partners, LLC
# t0 @$ b3 u/ Y1 s"Encapsulated Human Mesenchymal Stem Cells For Improved Islet Cell Therapy”- d; k7 E8 J8 g p8 M
3 _' U& Y+ @5 i1 {' x; z: s9 R
William Brandt) I7 O( K% B5 H
Johns Hopkins University- School of Medicine
8 ]7 [% _3 i" w. s8 o- `"Characterizing Notch Signaling in Bladder Cancer Stem Cells”
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. n& ?7 K3 b" L6 ?9 X/ ^- G& KNamshik Kim
6 l+ g" I% J7 y1 P2 [( ^Johns Hopkins University- School of Medicine+ m! Z+ }1 D' g
"Understanding The Role Of CYFIP1 Deletion/Duplication In Schizophrenia & Autism”& W$ v: e- p' R: e9 i3 i" P
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Julien Maruotti; M: ]! _! ^: C
Johns Hopkins University- School of Medicine1 T7 _0 C0 j% Y' e# ]$ @
"A High Content Screen for Small Molecules that Promote Stem Cell differentiation into Retinal Pigmented Epithelial Cells for Potential Treatment of Age-Related Macular Degeneration and Other Retinal Degenerations”
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a- R! d7 O% l6 B2 b: b& E9 B$ JTammy Morrish$ r7 z/ v) g# t* m! B
Johns Hopkins University- School of Medicine
0 D) J; S2 B* w% ?6 V. I) P; T"Telomere Recombination Mechanisms in Mesenchymal Stem Cells”% h4 p( ?6 M9 n! G9 U$ l
3 y# e" P4 \7 k# u$ ZAmanda Phillips( D! z5 n/ h# v; ~. U
Johns Hopkins University- School of Medicine
. C+ S/ r' X4 E"Focal Transplantation of Human Neural Stem Cell-Derived Astrocytes Isolated From Als Patients into the Rat Spinal Cord”" N* v& O( W7 p: I4 I8 i u
: E( t$ b0 |# k" D# y4 WPrakash Rath
. V L+ S8 d: j8 G: \! [" X% A5 THugo W. Moser Research Institute at Kennedy Krieger, Inc.+ o7 S* W( s6 `4 u# y p; N( \
"Modulating HGF/c-Met Signaling in Human Normal and Neoplastic Stem Cells”
6 R# [" k1 ]$ S8 A q2 W0 }
- c9 P- U# H& f; p* `! r2 W5 C8 qSandeep Shah
! t( d4 ]- R) x7 _% W% QJohns Hopkins University- School of Medicine
3 l$ f1 l" m4 G& w; H* w( Z$ dIn collaboration with Life Technologies, Inc.
3 Z5 @. [9 a; P/ x"HMGA Proteins in Stem Cell Survival and Induced Pluripotency”
- `. |/ {" E6 E" s' e% F; |1 ?9 [$ K! e7 }$ q
Shobana Shanmugasundaram
. } j+ }& L- jUniversity of Maryland, Baltimore - School of Medicine # ?9 @: O6 W* K, \. J
In collaboration with Biosurface Engineering Technologies, Inc.  Â
( ]( `: }3 {" J* h"Optimization of the 3D Scaffolds with Enzyme and Peptide for Osteogenic Differentiation in Stem Cells”
7 }* y: s- F. Z" A2 W& r" p1 e1 M7 P9 K, f
Yang Song
8 `" d7 n$ P( G4 f) F$ }! q) F: C3 TJohns Hopkins University- School of Medicine
, h: K! m" P1 `0 [* U- j) H% d; u+ wIn collaboration with Innovative Biosensors, Inc.: @$ g# f- _' l+ u. D$ f; w( F
"Signals Cooperating with RUNX1 to Specify Adult HSC from hESC”+ [& w) s e& P
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Juan Song) q$ ?$ f; @4 X9 a1 v4 }2 J/ e. K6 k, S
Johns Hopkins University- School of Medicine
. z1 d- ?: a+ u: A0 A2 Q+ PIn collaboration with Life Technologies, Inc.! y! m5 l& w' o! i, [$ [ q! S
"Understanding the Mechanism of a Schizophrenia Susceptibility Gene Disc1 in Regulating Synapse Development Using Patient-Derived iPSCs”
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" T. U- m$ w' }: e/ j6 C6 rYijing Su1 D4 E" x$ m) d: [% q7 D* d
Johns Hopkins University- School of Medicine
2 {- s2 Z6 |2 _"Roles of Tet Proteins In Regulating DNA Demethylation And Differentiation of Human Pluripotent Stem Cells And Neural Progenitors”
( _5 A8 ^! H: Y' R/ {0 i" X9 _5 W, J3 q$ h% \; w0 [( Z3 k
Chiaochun Joanne Wang
, f9 _- V8 `/ g8 J) i7 J" YJohns Hopkins University- School of Medicine
I" M- h* u2 c3 {2 Z"Microvasculature Mimicking Microfluidics for High-Throughput Screening of Targeted and MR Trackable Stem Cells”
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) v6 u" E1 c% J8 eShuming Zhang. b2 ?2 r& x2 l" k3 G- Z
Johns Hopkins University- School of Medicine
/ h" |* D( k; Q# h1 X- {"Role of Electrical Stimulation on Differentiation of Human iPS Cells and iPS-Derived Neural Crest Stem Cells” |
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发表于 2011-5-27 21:59
