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Cells can communicate with each other through the
: J( k& \# ?1 R# isecretion of cytokines, small (8–30 kDa) soluble proteins.
$ e: }$ L2 g' t1 B" v. }! y- W) @To date, roughly 20 cytokines have been identified. Upon0 m% V4 A4 O) K. B
binding their cognate receptors, receptor-associated Janus
% C. Q3 y" s8 q& a# o8 L: EKinases (JAKS) phosphorylate tyrosine residues of the( m" u8 B2 u' }; g! n$ r
ligand-bound receptors, as well as interacting Signal
/ ?4 l! d: U: x+ \; U4 G+ kTransducers and Activators of Transcription (STATs).Tyrosine phosphorylated STATs form homodimers, shuttle
% L1 |: H* a6 b- O' ?% Pto the nucleus and participate in transcriptional regulation
- O: P6 v/ }( j1 D1 e% ?* u( }of a variety of genes
" G# n5 I$ y% N9 Y8 O- t) N6 b5 F0 z/ x) x* [
我标记的这一句,是什么意思呢 ,为什么我连语法结构都分析不过来呢,总感觉少了点什么!希望热心人给予解答! |
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