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Cells can communicate with each other through the
) Y+ y" p8 C& \* {4 J ~secretion of cytokines, small (8–30 kDa) soluble proteins.
% ]. v* L: Y: P) ]4 VTo date, roughly 20 cytokines have been identified. Upon6 K/ f+ G3 u5 U5 Q/ K3 c( U# g
binding their cognate receptors, receptor-associated Janus
' W7 `* O0 Z& f* e9 J3 z2 |$ T9 {0 TKinases (JAKS) phosphorylate tyrosine residues of the
* ^: ^9 T, Z! O* z1 c1 Nligand-bound receptors, as well as interacting Signal- N" @; W. }) X. y3 w! x
Transducers and Activators of Transcription (STATs).Tyrosine phosphorylated STATs form homodimers, shuttle
5 ?" w3 p, |% D4 ~8 C2 Ito the nucleus and participate in transcriptional regulation
/ T' G/ `, Q( P! eof a variety of genes
. C8 }. f# y5 p3 R; U+ e; \7 h
1 U3 y& @, n5 _* o: r我标记的这一句，是什么意思呢 ，为什么我连语法结构都分析不过来呢，总感觉少了点什么！希望热心人给予解答！ |
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发表于 2011-5-30 15:42
