重编程技术革命——niche reprogramming

sunsong7

基础细胞生物学告诉我们细胞分化方向由细胞质而不是细胞核操纵，细胞所处的微环境影响细胞分裂的不对称性，最终决定细胞命运。
+ `. V3 G$ ]9 K+ G8 M3 w" t8 v$ K& t细胞重编程(reprogramming)指细胞的表观遗传学（Epigenetics）重构，包括自发重编程（disease）和人为重编程（iPS）。
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* r! O& L  D6 W5 O  ]人工细胞重编程技术已经历了核移植重编程、整合DNA病毒重编程、miRNA重编程几个阶段，不久单纯的细胞因子重编程及化学小分子重编程技术也将实现..., [- E8 d6 R8 k$ D( l$ G+ A
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山雨欲来风满楼，激动人心的时刻即将到来，仅仅通过微环境调控对细胞质进行操纵，就可以实现细胞命运的无限变换——细胞微环境重编程（niche reprogramming ）

weaponboy

搬凳子学习。

abgg

观念上提出假说，假说有一定的合理性，但如何证明或证伪这个假说并不容易。重编程过程的捕捉还是需要一系列技术突破的。

sunhongmei

非常感谢！只是现在还下载不了，包包不够。继续努力

sunsong7

日本美女科学家研制新型万能细胞STAP  http://www.stemcell8.cn/thread-76112-1-1.html% ^% y+ I6 q( @9 E2 F) t
日本诱导干细胞研究再次发威（附原文） http://www.stemcell8.cn/thread-76054-1-1.html
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wangji5

这篇帖子好多精彩文献啊！！学习学习！！

626630192

回复 zyyzyy1985 的帖子
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5 |! ^. y5 W0 T4 `好文章

JOEL

回复 sunsong7 的帖子
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! B+ _2 D# v: n9 T6 _- K% xQuotation ------"子曰：上善若水 大成若缺  干细胞治疗的终极解决方案就是不使用外源干细胞（cell-free is the final solution of stem cell therapy ）"; e: ]1 K6 H  y6 F
This is wisdom!

JOEL

回复 sunsong7 的帖子
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Thanks for sharing this interesting in formation.
& V# w1 L- T3 R" E" uIf the theory really worked in the way that cancer is not a result of the so-called genetic mutation but a consequence of niche reprograming it would mean that 1) the evironment out of the nucleus and 2) the environment out of the cell and 3) the natural environment, i.e. macro-environment, have been playing a decisive role. And it would be a revolutionary finding that guides the anti-cancer research into a new stage!* w. c- Z) M% _9 z9 j. M8 [
To control the both micro-and-macro-environments, i.e. to stop the interaction between the micro-and-macro-enviroments will be the focus for against cancer. Or frankly, the key is how to stop the niche reprograming by barring any factors as the necessary conditions enviroments out of the nucleus. Mama mia it is still a great project!

sunsong7

iPS现原形——日本人培育出癌症干细胞 http://www.stemcell8.cn/thread-54789-1-1.html4 `) f$ t3 `9 u* {