iPS现原形——日本人培育出癌症干细胞（附原文）

FreeCell

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日本用ips细胞培育出癌症干细胞

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8 X+ s9 F) j9 r4 H3 N7 K- }2012年04月13日 18:36:40  来源： 新华网  新华微博     * }' q0 d) \9 O4 _; p- [2 }
    新华网东京４月１３日电（记者 蓝建中）诱导多功能干细胞（ｉＰＳ细胞）能发育成各种组织和脏器，但医学家担心它们发生癌变。日本研究人员１３日报告说，他们用小鼠ｉＰＳ细胞培育出了癌症干细胞，并确认其发展成癌细胞的过程，这将有助于提高ｉＰＳ细胞的安全性。
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/ ~" {4 P( T1 j6 G* g9 t/ |    日本冈山大学教授妹尾昌治领导的研究小组１３日在美国在线科学刊物《科学公共图书馆综合卷》上报告说，他们首先用小鼠细胞培育出ｉＰＳ细胞，然后向培养液中添加曾培育过肺癌、皮肤癌等癌细胞的液体，４周后将其中未分化的ｉＰＳ细胞移植到小鼠皮下。结果，小鼠全部患上了癌症，其部分癌细胞不断分化，还有一些癌细胞向肺转移，研究小组由此确认未分化的上述ｉＰＳ细胞就是癌症干细胞。* F3 J" E$ F; ?
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    研究人员同时发现，在普通培养液中用常规方法培育的ｉＰＳ细胞，移植后不会癌变，但如果与癌细胞一起培养，多数ｉＰＳ细胞会死亡。妹尾昌治指出，少数ｉＰＳ细胞癌变也许是受到癌细胞碎片或者其排出的分泌物影响。
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    研究小组认为，如果能更深入地了解ｉＰＳ细胞癌变过程及其发展成的癌细胞特点，将有助于预防和治疗癌症。由于癌症干细胞在肿瘤细胞中所占比例只有百分之几，采集非常困难，利用ｉＰＳ细胞培养成的癌症干细胞可供制药企业开发新药。
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! l! b' |& q7 t2 K* J1 k/ T12楼原文 感谢naturalkillerce 提供

FreeCell

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Japanese breed of iPS cells  to cancer stem cells

9 `- `: I2 I5 hPublished: 17:38:50 April 13,2012  Views: 3  Chinese Version
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% m  `! ?) V; K+ x7 A# v+ Q# c     Xinhua News Agency, Tokyo, April 13 (Reporter Lan Jianzhong) - Induced pluripotent stem cells (iPS) cells can develop into various tissues and organs, but physicians worry that they become cancerous. 13 Japanese researchers reported that cancer stem cells, they bred a mouse iPS cells and confirm its development into cancer cells, which will help to improve the security of iPS cells.
  A7 y9 Y& J# y# H. n) k    Research team led by professor at the University of Okayama, Japan, sister Mei Chang governance in the Public Library of Science of the U.S. online scientific journals << volume >> 13 reported that they first bred with mouse cells, the iPS cells, and then added to the culture medium had nurture the cancer cells of lung cancer, skin cancer and other liquids, after four weeks in which undifferentiated iPS cells transplanted into mice subcutaneously. a result, all mice suffering from cancer, some of their cancer cells continue to divide, some cancer cells metastasis to the lung, the research team thus confirmed that these iPS cells to cancer stem cells undifferentiated(http://www.agile-news.com/). 9 k% `4 O( t  a1 \
     The researchers also found that iPS cells cultivated in ordinary culture medium using conventional methods, the transplant will not cancerous, and cancer cells cultured with the majority of iPS cells will die. Sister Mei Chang governance pointed out that a small number of iPS cells to become cancerous may be due to cancer cell debris or discharges.
7 R: O" H& A9 i; u% j     The research team believes that, if a deeper understanding of iPS cells to become cancerous process and its development into a cancer cell characteristics will contribute to the prevention and treatment of cancer due to the proportion of cancer stem cells in the tumor cells only a few percent, collecting very difficulties, the use of iPS cells into cancer stem cells for pharmaceutical companies to develop new drugs. (End) / U0 O5 |- \9 E  x
http://www.agile-news.com/news-1289913-Japanese-breed-of-cancer-stem-cells-to-iPS-cells.html
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shiyi

iPS是如何变成cancer stem cell 的？哪些细胞因子起作用？根本没搞清楚啊。这些没搞清，“利用ｉＰＳ细胞培养成的癌症干细胞可供制药企业开发新药”就是天方夜谭

懵懂干细胞

即是一个好消息也算坏消息！ 期待下一步进展

细胞-77

求原文。谢谢！

future007

这是一个重磅消息9 Y' O  b# z; L& g+ T) w8 ]" a* x6 H

marrowstem

    记得去年有好几篇发在Nature等杂志上的paper说过，iPS细胞本身具有遗传上的不稳定性，并在不断的诱导或培养过程中，细胞自发突变产生癌细胞的可能性还是不小的。4 O# A2 ^, q1 w; o' n
    这个实验其实对iPS细胞的研究并不是一个好事，相反是他需面对的问题更多了一个，因为iPS细胞现出了他的一个原形。

dabai22222

这标题太over了，从文中看来跟iPS本身没有关系，如果用ES与cancer coculture估计也会发生一样的情况，这并不能说明iPS有问题，相反文中证明正常情况下培养的iPS并没有问题。

FreeCell

回复 dabai22222 的帖子
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  q+ |- J2 R! f* u# b  j3 x: z提醒楼上，不导入外来基因才是真正意义上的“重编程”

dabai22222

回复 FreeCell 的帖子
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不导入外来基因才是真正意义上的“重编程”--LZ这句话从何说起？