成体心脏自我修复的最新报道

pujixing

nature letter
; a3 X& e( O8 n( U, |  S0 z" [! Y" [) h$ n  n; P4 ]/ O6 G7 H+ @
De novo cardiomyocytes from within the activated
0 U0 b* G2 S7 S! qadult heart after injury' C: Q; y: _% @- f. d0 e4 m) Z5 H
Nicola Smart1*, Sveva Bollini1*, Karina N. Dube´1, Joaquim M. Vieira1, Bin Zhou2,3,4, Sean Davidson5, Derek Yellon5,
* @3 H- R0 x7 Y( ~0 \Johannes Riegler6,7, Anthony N. Price8, Mark F. Lythgoe6, William T. Pu2,3 & Paul R. Riley1
3 T; n, I7 o  I; `
- U! t+ ]- [5 t4 s5 {% ^5 LA significant bottleneck in cardiovascular regenerative medicine is" l& N8 ^2 b" o7 i1 f* a% ^# m. s
the identification of a viable source of stem/progenitor cells that
6 O) K3 D) W2 V- D8 U/ Xcould contribute new muscle after ischaemic heart disease and
+ J1 s( Q+ q6 Y- r0 L9 H: ^acute myocardial infarction1. A therapeutic ideal—relative to cell
$ K8 |5 [7 F9 x! ]8 Q- Z# v: \3 gtransplantation—would be to stimulate a resident source, thus' y, J7 Z/ y3 t9 j8 s) M7 }% \+ J$ i
avoiding the caveats of limited graft survival, restricted homing
3 Z' H( W) s5 k% i" w$ W5 Kto the site of injury and host immune rejection. Here we demonstrate  t# p/ M9 p2 H6 S7 ^2 u; O
in mice that the adult heart contains a resident stem or. l8 Q2 R2 X. L) f- ^; I8 t/ S0 z
progenitor cell population, which has the potential to contribute
, ?9 Q1 @% N6 c0 {: Fbona fide terminally differentiated cardiomyocytes after myocardial  G2 z3 f0 c3 w5 w  a9 p
infarction. We reveal a novel genetic label of the activated
6 v: d: Q" t$ u5 m9 j. Sadult progenitors via re-expression of a key embryonic epicardial8 Q) |6 U3 B2 M1 ]0 K
gene, Wilm’s tumour 1 (Wt1), through priming by thymosin b4, a) v2 p+ n( t* D: n! m
peptide previously shown to restore vascular potential to adult
  g# c. \  B3 g. C" Y& F4 Oepicardium-derived progenitor cells2 with injury. Cumulative9 D/ Z! A; _( b4 u; N
evidence indicates an epicardial origin of the progenitor population,
& Y- |% w1 M! u' }1 yand embryonic reprogramming results in the mobilization
+ I4 I0 L( }% P% ^/ Q; \* Xof this population and concomitant differentiation to give rise to de
0 Y# q/ h7 K; V# s& T( enovo cardiomyocytes. Cell transplantation confirmed a progenitor
: p: }7 o, a+ l4 A: s' l6 Vsource and chromosome painting of labelled donor cells revealed
* K. P* {' u6 q+ G- }+ u$ gtransdifferentiation to a myocyte fate in the absence of cell fusion.
! X3 q5 q# Y. G) }2 b7 XDerived cardiomyocytes are shown here to structurally and functionally
1 X/ k% T9 Z) p; t2 iintegrate with resident muscle; as such, stimulation of this
& K; O9 Z$ Z7 G7 R5 v$ dadult progenitor pool represents a significant step towards residentcell-0 ^  B- Y! D3 i9 O
based therapy in human ischaemic heart disease.

pujixing

全文：

tpwang

回复 pujixing 的帖子, p, H5 S/ P$ r- p+ W
3 R, o5 d. \$ W0 w
严格说应该叫（通过）外源性刺激激活心脏损伤内源性修复机制