成体心脏自我修复的最新报道

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nature letter6 W1 b4 n- t7 E6 c
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De novo cardiomyocytes from within the activated/ m! |6 h0 t; _0 P# `( u+ L
adult heart after injury
6 D/ S, I8 ~$ D; U: A0 a' h3 INicola Smart1*, Sveva Bollini1*, Karina N. Dube´1, Joaquim M. Vieira1, Bin Zhou2,3,4, Sean Davidson5, Derek Yellon5,
9 J/ I5 u$ T0 x% [Johannes Riegler6,7, Anthony N. Price8, Mark F. Lythgoe6, William T. Pu2,3 & Paul R. Riley1
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9 d, d- m9 p2 N/ p# T# b7 gA significant bottleneck in cardiovascular regenerative medicine is! L& r6 A% P) @; G
the identification of a viable source of stem/progenitor cells that9 U! n7 ~* ^) _# c# i
could contribute new muscle after ischaemic heart disease and+ X+ l" S1 C) n! f) _
acute myocardial infarction1. A therapeutic ideal—relative to cell
! K) Y/ M% ?( U$ C' ~( stransplantation—would be to stimulate a resident source, thus0 b6 {# h9 k+ X2 v
avoiding the caveats of limited graft survival, restricted homing
8 c$ A, W% P. \/ C4 k" fto the site of injury and host immune rejection. Here we demonstrate
" w- v* V* n3 R6 y/ y0 w" Iin mice that the adult heart contains a resident stem or
* ~- P* f8 w! [" eprogenitor cell population, which has the potential to contribute% Y  I: r3 s/ g  N
bona fide terminally differentiated cardiomyocytes after myocardial$ x! o0 C5 @  ~( S% Q! R# H
infarction. We reveal a novel genetic label of the activated
/ D( ]1 B6 @* Xadult progenitors via re-expression of a key embryonic epicardial
, L- O, W4 H3 q# A2 F' Igene, Wilm’s tumour 1 (Wt1), through priming by thymosin b4, a' X) s0 S3 I) @% O' v: J+ C
peptide previously shown to restore vascular potential to adult
- Z! L0 _  @! ~( m8 k& y7 B$ V: Xepicardium-derived progenitor cells2 with injury. Cumulative
# H2 Y& [" x' r8 a6 ?4 ~0 n) revidence indicates an epicardial origin of the progenitor population,, E9 o$ j8 e# X
and embryonic reprogramming results in the mobilization% G: S! j1 A$ N" U. ]" x0 R
of this population and concomitant differentiation to give rise to de7 _/ i9 z) `" h3 U& i
novo cardiomyocytes. Cell transplantation confirmed a progenitor
/ d: O5 o/ H# s& ^. @2 q6 ^source and chromosome painting of labelled donor cells revealed
$ u4 q1 w7 j0 z; G5 x) [; _transdifferentiation to a myocyte fate in the absence of cell fusion.  m: ^$ x$ Z9 [* M  {! F1 [
Derived cardiomyocytes are shown here to structurally and functionally
0 E5 v0 e1 j0 K5 H; ~9 h4 aintegrate with resident muscle; as such, stimulation of this
' R9 N  `% k$ {. k0 Vadult progenitor pool represents a significant step towards residentcell-7 Z. v- x- A  l) c. W! R, J& B0 \9 y6 Y: f
based therapy in human ischaemic heart disease.

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严格说应该叫（通过）外源性刺激激活心脏损伤内源性修复机制