重编程机制的研究——文献复习

tpwang

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. @! p7 n, S1 D4 CIan Wilmut也写了一篇综述，作为英国皇家学会会刊生物学卷关于干细胞和发育重编程的刊首文章。关于机制的猜想，也是提到了因子重编程的效率远低于核移植、细胞融合等其他重编程途径。提示这里面可能有卵或细胞环境本身具有人们尚未找到的促重编程因素和条件，或从另一个角度来说因子重编程需要的条件形成要花时间等。
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: w+ W2 i5 F. N1 U% x2 n8 P1 Q皇家会刊名称的限定词为“Philosophical Transactions of"，文章一般不是传统的技术性科学研究报告。 1 ?& D' ]0 \6 u; S' u3 M

' D2 e5 Z2 r' p+ b) T" }关于重编程的限度Wilmut问道：* {9 ~2 N! m' ^( d8 S
However, the limitations to our opportunities to change cell fate are still not clear. Is it possible, for instance, to produce any cell type from any donor cell type, given the introduction of the necessary regulatory molecules and an appropriate culture environment?2 _, B% Y; D( K) w6 S
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关于重编程的细胞治疗临床可能性老头儿推断：
4 o: D3 q* K9 \- |0 }In all likelihood, cell therapy will not be possible for all degenerative and genetic diseases for reasons that we cannot yet foresee. Furthermore, the development of treatments will almost definitely
+ U7 {$ i! J2 C2 [( m$ Lhappen over a period of decades, and not merely years.- a7 ^( C& S, T% |$ U
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作为重编程的里程碑式人物，其反思也许有特殊的意味。
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