重编程机制的研究——文献复习

aidiulgy9517

回复 tpwang 的帖子+ N' c: A4 N: D0 c

1 Z# z% V' i5 f大作拜读，不乏高见，受益匪浅，感谢分享！

BioMan

Very interesting and beneficial articles, although I don't know Chinese.
. r3 u( R# `% K0 aIs there any other post like this, summarising or listing literature articles, in other aspects of stem cell field?
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% R9 ~7 U  o8 k% {2 dThank you very much.  

BioMan

Very interesting and beneficial articles, although I don't know Chinese. 6 H6 I# z: N: j
Is there any other post like this, summarising or listing literature articles, in other aspects of stem cell field?% D" R5 B+ R$ ]4 [. u
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Thank you very much.  

tpwang

回复 bathpp2007 的帖子
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thanks for the correction.

tpwang

cicadacjk 发表于 2011-6-29 22:28
5 ~  ^2 `' [0 V6 |* ]* _' u& r$ K9 [我认为细胞命运决定需要提出一个更加普遍性的理论，要花很长时间。. l8 ]# l: q. U
因为目前从内部因素到外部因素，决定细 ...

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Good observation.7 \8 S$ j2 {- V: W! o/ k0 u3 X
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从另一个角度来说，如果重编程确实是发育过程的逆转，或某种逆转式的复制，人们对发育过程的理解还很粗浅，因此对重编程的机制的认识就无法有一个成熟的参照系，只能是摸索。反过来说，过去对发育的研究受到很多无法逾越的困境的限制，而重编程可能提供了一个比较接近的反向模拟手段。从这个意义上来说，重编程及其机制的研究也会促进对发育过程的理解。未来的过程就是一个交互递进的过程，也许彻底认识发育过程的时刻也就是彻底认识重编程的时机，vise versa。7 z" U+ G9 G& Y9 U) B6 [

$ L: u- N5 O5 u/ S' _至于体外重编程或者多能性是否具有跨物种的保留，或在多大程度上保留，以什么方式保留，也不仅是个生物学问题和研究手段借鉴的问题。Conservation程度一定会根本上影响重编程和多能性的人类利用。% f) ]: a7 P  X  B7 D
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成体再生能力的保留与胚胎干细胞的体外可获得性，在不同进化阶段种属动物的状况，值得关注。朴素的想法来推断，成体再生能力越强的，是否也越保留了发育阶段的多能性，或者是恰恰相反。分离方法和体外状态是个纯技术问题还是也折射了不同物种的本质状态。

hormone008

版主给力啊！
% \9 Y6 {7 Y0 A' V辛苦了！
# I+ V0 N& N: Z: l9 N赶紧集中学习一下！
! g  I. X" l- Y. F- T! _谢谢！

tpwang

回复 BioMan 的帖子1 m, ?; }) [& n& k0 y4 Y

% d( G7 i% Q2 ~8 @Thanks.
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3 A9 Z" ]5 m- M; J; iMost of the posts here are in Chinese. Posts in English with reasonable degree of difficulty for Chinese students and scholars to comprehend may also elicit good responses and discussions.
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BioMan

@tpwang, q, z/ I& {/ Q2 m/ K/ M, b

1 \/ G  t+ ^% g$ X  D8 w0 PYes I agree, but could you please refere with links to these posts (even in Chinese). I will do my best to comprehend and will of course benefit from the lists of literature (articles and review) to keep a chronological record of the field  and for my own reading.5 L( E' G6 D+ c/ L
I hope there are other posts which list in chronological order the milestones articles in Cancer Stem Cells, Haematopoeitic Stem Cells, Mesenchymal Stem Cells, and so on.... even method and assays in Stem Cells. 9 }$ e9 ^. }/ v5 N

; p9 G# d8 d- K# I/ w3 HThank you so much.

tpwang

回复 BioMan 的帖子
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Don't know much about cancer stem cells, haematopoetic, mesenchymal..., but here is one link for iPSC disease model: 3 Y% W1 a( d! \6 \; d' z7 P
http://www.stemcell8.cn/thread-37278-1-1.html8 A1 {; ~' w8 B# v0 x% O- O) X
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hualin840518

回复 tpwang 的帖子$ F9 x2 x4 `7 T( S. Y* M. D
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很好，很强大，你读了这么多文章，真的很了不起，佩服！
" j: O" N% a% m3 s5 a, z还能把阅读心得与大家无私分享，值得学习！, Z2 Z; M) H) T! s* d
感谢！