Cell of Origin in AML: Susceptibility to MN1-Induced Transformation Is Regulated

饶冠华

Cell of Origin in AML: Susceptibility to MN1-Induced Transformation Is Regulated by the MEIS1/AbdB-like HOX Protein Complex( T! D* _' _) U) E8 k% A
M. Heuser, H. Yun, T. Berg, E. Yung, B. Argiropoulos, F. Kuchenbauer, G. Park, I. Hamwi, L. Palmqvist, C.K. Lai, M. Leung, G. Lin, A. Chaturvedi, B.K. Thakur, M. Iwasaki, M. Bilenky, N. Thiessen, G. Robertson, M. Hirst, D. Kent, N.K. Wilson, B. Göttgens, C. Eaves, M.L. Cleary, M. Marra, A. Ganser, and R.K. Humphries3 [( j! T5 q* U  J
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The cancer stem cell concept postulates a hierarchical organization of tumors with cancer stem cells residing at the top of this hierarchy. Whether cancer stem cells derive from normal stem cells or whether committed cells reacquire stem cell properties during transformation remains elusive. Moreover, pathways determining cellular susceptibility to transformation have not been characterized. Employing single cell transformation of prospectively isolated hematopoietic stem and progenitor cells, Heuser et al. identify a narrow window of transformation susceptibility during hematopoietic differentiation. Transformation susceptibility required the activity of a well-characterized self-renewal pathway. Inhibition of this pathway demonstrated antileukemic activity, suggesting that transformation susceptibility may be a therapeutic target in a wide range of malignancies.% W3 A1 ]% K  J* ~: U

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