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Thinning microtubules [复制链接]

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发表于 2009-3-5 21:17 |只看该作者 |正序浏览 |打印
作者:During anaphase, microtubules (green) are released from the centromere and move toward the poles. 9 X- j% d8 V% X8 @! w
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                  Centrosomes spit out microtubules to thin out their load at the end of mitosis, as illustrated by Rusan and Wadsworth on page 21. This reorganization helps reestablish the interphase microtubule array and may contribute to localizing the cytokinetic ring.
5 W# |- U0 `; ~& t4 d1 j4 N1 lCentrosomes nucleate many more microtubules during mitosis than they do in interphase. The new results show that the extra load is lightened in mammalian cells at late anaphase, when microtubules were released both individually and in clusters. The clusters carried with them centrosomal proteins such as -tubulin, the microtubule nucleator. The release of microtubules is prevented by CDK activity, as nondegradable cyclin B inhibited the disassembly after chromosome separation.
, O9 `) J! u3 U. V1 xMicrotubules were released and actively transported outwards in the direction of the cell poles (away from the chromosomes), where microtubules were previously scarce. Because the freed microtubules are not protected at their minus ends, they are more dynamic and turn over more rapidly than attached microtubules. The microtubules or their subunits are probably used to reform the interphase array.! w" b* V) w: [! i
The bias in turnover also creates an asymmetry in the array that might be important for directing cytokinesis to a central location. The attached, stable microtubules (those pointing inward) are more likely to transport signals that might stimulate the formation of the cytokinetic ring. " C7 ?0 B  G1 W- i1 p
Nicole LeBrasseur
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- E2 P7 z8 B5 g( ]& \, ANasser M. Rusan and Patricia Wadsworth# }+ e1 b6 G( v+ z, h4 e2 a0 N
J. Cell Biol. 2005 168: 21-28.

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发表于 昨天 10:54 |只看该作者
加油啊!偶一定会追随你左右,偶坚定此贴必然会起到抛砖引玉的作用~  

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发表于 4 天前 |只看该作者
世界上那些最容易的事情中,拖延时间最不费力。  

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发表于 2025-5-13 11:56 |只看该作者
干细胞之家微信公众号
老大,我好崇拜你哟  

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发表于 2025-5-2 19:21 |只看该作者
风物长宜放眼量  

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发表于 2025-4-13 23:41 |只看该作者
牛牛牛牛  

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发表于 2025-4-11 04:15 |只看该作者
长时间没来看了 ~~  

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发表于 2025-3-30 04:54 |只看该作者
真是天底下好事多多  

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发表于 2025-2-25 01:08 |只看该作者
天啊. 很好的资源

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发表于 2025-2-22 23:10 |只看该作者
谁能送我几分啊  
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