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本帖最后由 细胞海洋 于 2011-8-20 22:02 编辑 6 [+ R3 K# @: B% W
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目录:) R2 j4 G: [: o A/ S0 b
In This Issue
; s) z8 r, J! t( oIn This Issue p489 ; _4 N+ j8 J6 z9 p
3 U8 B5 l m; h ZSelect3 B( `0 m- n' l8 V7 K
Remote Control: The Brain and Beyond p493 / z" B: |. d; ~, R. v- S& b
0 l$ |' Q+ y) d; P% ePreviews. q/ G/ x, H2 K" \1 v; c& O
Transcription Factor Loading: Please Take My Place! p497 0 P ~8 ?4 U5 g( B! W
Markus Stratmann, Ueli Schibler; P7 d/ Y/ y: E; F
Travel Notes from the Equatorial Circle p499
7 |+ s: \9 }4 YAndrea Musacchio
* l% }) M3 p4 J/ J7 Y+ p1 ~; tElongated Membrane Zones Boost Interactions of Diffusing Proteins p501
, l. i: ]0 V- jJoshua Zimmerberg, Samuel T. Hess
; B9 M0 |6 }4 RMeeting the (N-Terminal) End with Acetylation p503
/ P0 v. J' w: {& C/ E! h1 [Joshua L. Andersen, Sally Kornbluth( q T& g- B% B
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Commentary
# J4 {6 A: {5 k9 E4 F8 |$ EOrganizing Graduate Life Sciences Education around Nodes and Connections p506
7 j2 N. S- \) A% B/ t: LJon R. Lorsch, David G. Nichols
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Perspective
; B' s2 v( S4 l* x3 AMechanisms for the Inheritance of Chromatin States p510 ' `4 |% X" \! Z
Danesh Moazed
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Articles* {' |3 J3 ~, g4 I' x0 u: y
Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells p519
0 b9 B6 W* m2 @/ O$ `& G1 XKatsuhiko Hayashi, Hiroshi Ohta, Kazuki Kurimoto, Shinya Aramaki, Mitinori Saitou
; U2 m2 D+ K( l- Q# eLinking RNA Polymerase Backtracking to Genome Instability in E. coli p533
* k9 e' w( g/ ~0 T2 w C6 S8 }Dipak Dutta, Konstantin Shatalin, Vitaly Epshtein, Max E. Gottesman, Evgeny Nudler
, \- r$ R a& |* ]1 |2 ODynamic Exchange at Regulatory Elements during Chromatin Remodeling Underlies Assisted Loading Mechanism p544
, K- v8 _1 x9 mTy C. Voss, R. Louis Schiltz, Myong-Hee Sung, Paul M. Yen, John A. Stamatoyannopoulos, Simon C. Biddie, Thomas A. Johnson, Tina B. Miranda, Sam John, Gordon L. Hager
7 C- a* A# K& w& ^The Spatial Arrangement of Chromosomes during Prometaphase Facilitates Spindle Assembly p555
4 l& `) o# F9 k, C4 U& AValentin Magidson, Christopher B. O'Connell, Jadranka Lon?arek, Raja Paul, Alex Mogilner, Alexey Khodjakov/ L q k( I" B. E, Q
Complete Kinetochore Tracking Reveals Error-Prone Homologous Chromosome Biorientation in Mammalian Oocytes p568 0 T1 g" u V4 V- k
Tomoya S. Kitajima, Miho Ohsugi, Jan Ellenberg0 r2 f- y) o& M% n: T, Q& e+ L
Rapid Microtubule Self-Assembly Kinetics p582
' [$ x+ z5 Y5 WMelissa K. Gardner, Blake D. Charlebois, Imre M. Jánosi, Jonathon Howard, Alan J. Hunt, David J. Odde
8 Q( L& x J! Y4 z* u" n, CCytoskeletal Control of CD36 Diffusion Promotes Its Receptor and Signaling Function p593
0 W+ N x, p! M& j0 y& ~Khuloud Jaqaman, Hirotaka Kuwata, Nicolas Touret, Richard Collins, William S. Trimble, Gaudenz Danuser, Sergio Grinstein
1 t) V; _. i( e# AMetabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival p607 1 b! V6 t0 T! d, X+ ?0 V
Caroline H. Yi, Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts, Gregory J. Heffron, Matthew G. Vander Heiden, Renliang Yang, Fupeng Li, Jason W. Locasale, Hadar Sharfi, Bo Zhai, Ricard Rodriguez-Mias, Harry Luithardt, Lewis C. Cantley, George Q. Daley, John M. Asara, Steven P. Gygi, Gerhard Wagner, Chuan-Fa Liu, Junying Yuan# {4 X1 c7 _+ A* z S6 D
Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons p621 - K5 l! N% a6 l9 V" F
Christoph Thomas, Ignacio Moraga, Doron Levin, Peter O. Krutzik, Yulia Podoplelova, Angelica Trejo, Choongho Lee, Ganit Yarden, Susan E. Vleck, Jeffrey S. Glenn, Garry P. Nolan, Jacob Piehler, Gideon Schreiber, K. Christopher Garcia. p' @* b* |! l
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Theory
2 u3 v2 N; s- S; x- ]5 BStochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells p633 ' u8 Z1 H1 }( a4 i
Piyush B. Gupta, Christine M. Fillmore, Guozhi Jiang, Sagi D. Shapira, Kai Tao, Charlotte Kuperwasser, Eric S. Lander
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0 E+ n* u$ ^2 _Resource
" Q" O/ y# k& `3 U3 D+ `+ mThe Human Mitochondrial Transcriptome p645
% l, u( I/ K$ Z5 ~3 l' jTim R. Mercer, Shane Neph, Marcel E. Dinger, Joanna Crawford, Martin A. Smith, Anne-Marie J. Shearwood, Eric Haugen, Cameron P. Bracken, Oliver Rackham, John A. Stamatoyannopoulos, Aleksandra Filipovska, John S. Mattick1 O6 l) F% k# \
2 X4 @0 e' T( ~. q2 pErratum
! `# \+ }8 j9 z h) f2 S: QGeneration of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations p659 0 ]# f* I: W$ o- w6 e
Frank Soldner, Josée Laganière, Albert W. Cheng, Dirk Hockemeyer, Qing Gao, Raaji Alagappan, Vikram Khurana, Lawrence I. Golbe, Richard H. Myers, Susan Lindquist, Lei Zhang, Dmitry Guschin, Lauren K. Fong, B. Joseph Vu, Xiangdong Meng, Fyodor D. Urnov, Edward J. Rebar, Philip D. Gregory, H. Steve Zhang, Rudolf Jaenisch/ J3 X$ `4 K; @- Q1 d! J5 \: @9 R
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SnapShot: Dendritic Cells p660 # x, I) C/ M0 J/ {2 x# j
Juliana Idoyaga, Ralph M. Steinman
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