Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

饶冠华

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung
' u: G+ U( L( `9 B* gZ. Granot, E. Henke, E.A. Comen, T.A. King, L. Norton, and R. Benezra- I* f& a0 w% l  V  Z
                  
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# f& A  g; [" E& O+ s% _Metastasis represents the final stage in cancer progression and is the primary cause for cancer-related mortality. Disseminated cells that are capable of colonizing distant organs and forming metastases therefore present an important therapeutic challenge. This study shows that during the premetastatic phase in multiple murine breast cancer models, neutrophils stimulated by the primary tumor accumulate in the lung. These neutrophils acquire a cytotoxic phenotype and provide antimetastatic protection by eliminating disseminated tumor cells. Although the neutrophils are eventually outcompeted by continued influx of metastatic cells, infusion of exogenous neutrophils effectively blocks metastasis and therefore represents a potential therapeutic strategy for management of micrometastatic disease.8 M  k8 W, U( z$ O( Q/ |8 k

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