用生态学原理为癌症造模

sunsong7

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新研究使用的Tilman模型來研究前列腺細胞的成骨轉移
6 t- A/ w8 C, I6 s" GPublished on October 3, 2011 at 4:29 AM · No Comments   http://www.news-medical.net/news ... lified-Chinese.aspx4 G4 X8 u% r! E* Q3 E
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Tweet inShare0成为一个既定的生态系统的一个新物种的入侵，可以直接与癌症转移所涉及的步骤。新的研究发表在BioMed Central的开放获取期刊理论生物学和医学模型使用的入侵物种之间的竞争蒂尔曼模型研究前列腺细胞的成骨转移。
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大约40,000人在美国每年有显然是成功的手术或放射治疗前列腺癌将遭受无法治愈他们的疾病，在骨转移。前列腺细胞侵入骨髓，有时经过多年其余休眠，竞争与造血干细胞和骨微环境。
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蒂尔曼模型研究入侵物种的各个组成部分的环境。陈坤环和来自密歇根大学的肯尼斯约瑟夫Pienta的蒂尔曼方程代入癌症进展中的步骤。最初乘以发生基因突变的前列腺内（相当于进化）后，癌细胞离开前列腺和进入流通领域。下一步是入侵成骨流通的生存期。
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: E& U- K5 s; n2 Q( P一旦骨有一个“滞后期”，而细胞建立自己。最终，癌症细胞开始繁殖和进行竞争的造血干细胞。陈坤环解释说，“入侵的癌细胞可以被认为是几个物种，以及优胜劣汰的突变体成为主导和繁殖，最终对生物圈（人类宿主）有一个巨大的冲击。”
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教授Pienta继续说，“是众所周知的毁灭性的生态入侵。，例如毛里求斯国内动物灭绝的渡渡鸟和蕨藻taxifolia，一个突变的杀手藻类的结果，是困扰地中海。癌转移如下类似的路径生态入侵和适应我们的蒂尔曼方程演示了如何入侵的癌细胞可以破坏正常的身体栖息地生态模型的使用，可以帮助我们理解复杂的生物学转移。“ . y' F" h5 p% z: t
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Modeling invasion of metastasizing cancer cells to bone marrow utilizing ecological principles.
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2 _4 T4 ]) s6 F8 @8 H3rd of October 2011 @ 05:50 | Source: BioMed Central Tweet7 d5 _9 L& @! I; g
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Background: The invasion of a new species into an established ecosystem can be directly compared to the steps involved in cancer metastasis. Cancer must grow in a primary site, extravasate and survive in the circulation to then intravasate into target organ (invasive species survival in transport). Cancer cells often lay dormant at their metastatic site for a long period of time (lag period for invasive species) before proliferating (invasive spread). Proliferation in the new site has an impact on the target organ microenvironment (ecological impact) and eventually the human host (biosphere impact). Results: Tilman has described mathematical equations for the competition between invasive species in a structured habitat. These equations were adapted to study the invasion of cancer cells into the bone marrow microenvironment as a structured habitat. A large proportion of solid tumor metastases are bone metastases, known to usurp hematopoietic stem cells (HSC) homing pathways to establish footholds in the bone marrow. This required accounting for the fact that this is the natural home of hematopoietic stem cells and that they already occupy this structured space. The adapted Tilman model of invasion dynamics is especially valuable for modeling the lag period or dormancy of cancer cells. Conclusions: The Tilman equations for modeling the invasion of two species into a defined space have been modified to study the invasion of cancer cells into the bone marrow microenvironment. These modified equations allow a more flexible way to model the space competition between the two cell species. The ability to model initial density, metastatic seeding into the bone marrow and growth once the cells are present, and movement of cells out of the bone marrow niche and apoptosis of cells are all aspects of the adapted equations. These equations are currently being applied to clinical data sets for verification and further refinement of the models.
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3 w7 f* z) W, t% f! uModeling Cancer Using Ecological Principles- S. U& Q+ r4 @1 T9 o: I2 [) z" x/ O

) H0 d4 Y9 C2 y5 Q9 n% C! GScienceDaily (Oct. 2, 2011) — The invasion of a new species into an established ecosystem can be directly compared to the steps involved in cancer metastasis. New research published in BioMed Central's open access journal Theoretical Biology and Medical Modellinguses the Tilman model of competition between invasive species to study the metastasis of prostate cells into bone.4 u6 J8 s+ P9 o2 X( w  x: ^
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Approximately 40,000 men a year in the US who have apparently successful surgery or radiotherapy for prostate cancer will suffer incurable metastasis of their disease in bone. The prostate cells invade the bone marrow and, sometimes after years of remaining dormant, compete with hematopoietic stem cells and take over the bone microenvironment.6 \8 g) k" e' Z' i
The Tilman model examines various components of invasion of species into an environment. Kun-Wan Chen and Kenneth J. Pienta from the University of Michigan substituted steps in cancer progression into the Tilman equations. After initially multiplying and undergoing genetic mutation (equivalent to evolution) within the prostate, the cancer cells leave the prostate and enter the circulation. The next step is a period of survival in circulation followed by invasion into bone.
9 e" d1 ~, p5 z# L' T# rOnce in the bone there is a 'lag period' while the cells establish themselves. Eventually, the cancer cells begin to multiply and out-compete the hematopoietic stem cells. Kun-Wan Chen explained, "The invading cancer cells could be thought of as several species, and the fittest mutants become dominant and multiply. Eventually there is a massive impact on the biosphere (human host)."6 O; y; t5 ~1 @4 y
Prof Pienta continued, "Devastating ecological invasions are well known. For example introduction of domestic animals to Mauritius resulted in extinction of the dodo and Caulerpa taxifolia, a mutated killer algae, is plaguing the Mediterranean. Cancer metastasis follows a similar path to that of ecological invasions and our adaptation of the Tilman equations shows how invading cancer cells can destroy the normal body habitat. Use of ecological modeling can help us understand the complex biology of metastasis."
3 M' o: p" |( K% z* khttp://www.sciencedaily.com/news/health_medicine/stem_cells/
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goodboy

我觉得生物做得越细致就会发现其实很多宏观上的原理在微观上也适用，比如肿瘤干细胞学说中的niche，欢迎大家发表不同意见

naturalkillerce

回复 sunsong7 的帖子
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After initially multiplying and undergoing genetic mutation (equivalent to evolution) within the prostate, the cancer cells leave the prostate and enter the circulation.翻译为“在前列腺内，癌细胞在初始的增殖和经历遗传突变(相当于生态系统中的进化)之后，它们离开前列腺和进入流通领域”或许更好，而不是“最初乘以发生基因突变的前列腺内（相当于进化）后，癌细胞离开前列腺和进入流通领域”。

tjbone

学习谢谢了