求关于小分子在iPSCs诱导过程中的作用有关文献

genedu

各位大虾，谁手里有关于替代OCT4，SOX2，Klf4，c-Myc这四个因子以及其他诱导因子的小分子的文献？小弟拜谢了
# s& e; W# r% e. i# I# z如果有哪位神人实际操作过的，请告知小分子名称及其用量。( }$ Y6 {/ h7 c- t4 p$ [8 l
再次拜谢

genedu

回复 cellbuddies 的帖子
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真是太感谢了。临帖涕零，不知所言

cellbuddies

MEK inhibitor PD0325901 (Sigma, 0.5 μM)/ k: K/ X% d2 T$ `+ d
ALK5 inhibitor A-83-01 (Tocris Bioscience, 0.5 μM)
" d* z4 R0 s; D# h& oGSK3β inhibitor CHIR99021 (BioVision, 3 μM)* ^5 M4 b2 ]) r, C% |
挺贵的，大概5000大洋

cellbuddies

full text

cellbuddies

可以参考丁盛的文章，给你一个文章列表0 {3 s/ O% \6 u1 ]" t: c
Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors% O% u% U) C4 u/ w( _# \
Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming
) W2 J, L6 \; L6 c' F  ]1 s" i9 XA chemical platform for improved induction of human iPSCs-supplemental methods and data+ d7 a& c+ R& C& I8 y: N% k# p
还有University of Cambridge的Austin Smiths
0 J- [/ U5 i, z- i6 |Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition