求关于小分子在iPSCs诱导过程中的作用有关文献

genedu

各位大虾，谁手里有关于替代OCT4，SOX2，Klf4，c-Myc这四个因子以及其他诱导因子的小分子的文献？小弟拜谢了
( d& N, ^: r9 z  z- v0 s7 S# z如果有哪位神人实际操作过的，请告知小分子名称及其用量。
; h2 H% Q7 _4 k1 h7 V: x5 p  p+ W再次拜谢

cellbuddies

可以参考丁盛的文章，给你一个文章列表
# z' H* V" O; N" aGeneration of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors
9 Q' t+ S# e: O9 M0 tSmall molecules that modulate embryonic stem cell fate and somatic cell reprogramming9 Z9 h& Z9 Y) g( ~" Q1 p$ j! f
A chemical platform for improved induction of human iPSCs-supplemental methods and data7 A! t  l) P( b; p' g
还有University of Cambridge的Austin Smiths
: ]( `8 f* R, Z) ~0 j4 `6 xPromotion of Reprogramming to Ground State Pluripotency by Signal Inhibition

cellbuddies

full text

cellbuddies

MEK inhibitor PD0325901 (Sigma, 0.5 μM)
% H* a) s9 N1 ^+ Z0 k/ x) ~ALK5 inhibitor A-83-01 (Tocris Bioscience, 0.5 μM)
+ e0 z  Q3 l1 E6 J$ ZGSK3β inhibitor CHIR99021 (BioVision, 3 μM)& C; v5 q7 @2 q: e# k9 o
挺贵的，大概5000大洋

genedu

回复 cellbuddies 的帖子( O2 l! E* y) i3 N
% ?, \  K+ r/ k& W
真是太感谢了。临帖涕零，不知所言