迄今为止最大规模的心脏干细胞临床研究收锚启航

naturalkillerce

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/ b' o3 \9 \/ ~, }4 t. snaturalkiller导语：在得到欧盟委员会提供的1170万欧元资金资助后，两项相关联的将证实干细胞治疗是否能够挽救心脏病病人生命的临床研究于2011年12月2日正式收锚启航。+ n& H- v6 }6 w+ R- _

" [" a7 p& A6 Y2 n; q) m& ULargest ever heart stem cell studies get underway5 L  |' N2 |- B" S  ^' B
December 2, 20117 F. l6 j( J/ z5 H2 O* x
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Professor Anthony Mathur (Queen Mary, University of London and Barts and the London NIHR Cardiovascular Biomedical Research unit) and Professor John Martin (UCL and University College Hospitals NHS Foundation Trust) have received the combined funding to establish the two international trials, which will be led by their respective institutions in London.' `: ~0 l+ \/ e

! _6 J1 ~2 f! A5 }The first study (BAMI) is a definitive 3,000 patient trial that will involve patients having their own stem cells taken from their bone marrow and injected into their heart within five days of suffering a heart attack. This trial is an expansion of a smaller clinical study performed at Barts and UCLH that demonstrated the safety of this technique. BAMI is much larger, involving 21 partners in 11 European countries. The results will be announced in five years and will demonstrate whether this treatment saves lives.  r7 T/ M, g# d$ ]+ W
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The second study (BIOMAGSCAR) involves eight partners in five countries and aims to build a new lining of the artery in the heart after heart attack by using a novel stent. Stents are artificial tubes inserted into a natural passage in the body to prevent or ease constricted blood flow. This new stent is magnetised and designed to dissolve once it has attracted the patient’s own stem cells to create a new lining of the artery.9 c. v( m5 b1 E& T
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Commenting on the BAMI trial, the Chief Investigator Professor Mathur said: “This is the first study that will allow us to measure whether stem cell therapy means the difference between life and death for heart attack patients. A number of smaller trials have already shown promising results by restoring cardiac function in heart disease patients by using adult stem cells to replace damaged heart cells. Now we want to take research to the next level and measure the two-year survival rate following stem cell injections.# e5 ~+ m' a$ h" Z+ [5 T: x6 u

; F/ F% q* w" Q9 d& [“We hope to prove that stem cell injections will reduce the number of people dying from heart attacks by 25% across Europe. After 15 years of research in the stem cell field this is the next step and could lead to life-saving treatments for millions of heart patients.”2 L3 y. ^0 G9 c8 C9 R6 O* `& h

8 g# `2 l7 X7 Q$ NCommenting on the BIOMAGSCAR trial, Professor Martin said: “Over 1.5 million stents per year are currently used in Europe and although they have improved patient outcomes, stents still fail.
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1 q6 @$ [0 D5 l0 Z2 g. A/ h“The novel concept we propose is the use of a biodegradable magnetisedstent with the ability to attract the patient’s own stem cells, which have been ‘tagged’ with iron nanoparticles. The cells will then multiply and form a new artery lining. We believe this technology could save over 66,000 people from unnecessary suffering, as well as saving the European healthcare system

三笑

拋锚还是启航?

naturalkillerce

回复 三笑 的帖子
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呵呵，想文雅一些，没有考虑太多，谢谢指出，已经修改。

avonzs

不错哦~~~希望有进展

一一

准确的说，欧洲投资自体骨髓源干细胞治疗心脏病研究，势必通过临床实验# L4 e0 |& J) u1 @# s/ X. s" X
评价安全性将其临床应用，而后发展组织工程支架，将拯救66000人的生命。看来欧洲也看好了间充质哦。
3 X1 x/ i3 t+ P2 z% y& |3 d* {! ]只是他们选择自体来源，这一点是从安全角度出发吗？8 i9 b. w1 y$ [4 `0 q- X! t. I
不知道异源会有什么不同。
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