《细胞-免疫》[Immunity]12年2月24日出版pdf全文

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    On the cover: Circadian rhythms are sustained by a molecular clock and provide a temporal framework ensuring the coordination of homeostatic processes with the periodicity of environmental challenges. Silver et al. (pages 251–261) show that the circadian molecular clock controls the expression and function of the pattern recognition receptor TLR9. In a vaccination model using TLR9 ligand as adjuvant, they demonstrate that mice immunized at the time of enhanced TLR9 responsiveness present weeks later with a substantially improved adaptive immune response. These findings unveil a direct molecular link between the circadian and innate immune systems. This link, which may have important prophylactic and therapeutic implications, is represented on the cover by a “circadian” digital watch indicating TLR9 as the current time. Cover art by Juan Ignacio Barbieri.0 t+ \/ R; Z0 X8 Q2 ?! t2 u
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