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本帖最后由 细胞海洋 于 2012-3-23 23:34 编辑 3 s; d7 P$ l6 c
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On the cover: Glycans cover the surface of all mammalian cells; they are added to protein and lipid backbones during their biosynthesis via a process called glycosylation. Programmed remodeling of cell surface glycans can modulate critical immunological processes, including immune cell activation, differentiation, trafficking, and homeostasis. In this issue of Immunity, Rabinovich and Croci review the mechanisms via which distinct families of glycan-binding proteins, such as galectins, C-type lectins, and siglecs (background), decode the information encrypted by the “immune cell glycome” and translate this information into regulatory circuits that amplify or silence immune responses, notably those related to autoimmunity and cancer. The current wealth of preclinical information allows the visualization of strategies through which manipulation of lectin-glycan interactions may contribute to restore tolerance and dampen pathogenic autoimmune responses or to break tolerance to promote tumor regression. Deciphering the information encrypted by the “QR code” will reveal a major message that will be discussed in the review (pages 322–335). Cover art by Paola Braile and Pepe Marriot (Aquiesdonde, Buenos Aires).
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发表于 2012-3-23 20:30
