ips能贡献到TE上吗？

xiaojunhu1985

是可以的，对于小鼠的是可以了，对于小鼠IPS的全能性的鉴定的是tetraploid complementation.这个也发表文章啦，但是对于hiPS就没法验证，只能做畸胎瘤。iPS cells produce viable mice through tetraploid complementation.
. T( N( r8 s+ F3 J. V# k* K4 N2 iZhao XY, Li W, Lv Z, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng F, Zhou Q.
8 X1 l6 y/ |# i+ QSourceState Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
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xiaojunhu1985

Tetraploid complementation assay  
5 J5 s  I) u- z3 c7 t% Ehttp://en.wikipedia.org/wiki/Tetraploid_complementation_assay
! ]3 W) J7 F- d3 aNormal mammalian somatic cells are diploid: each chromosome (and thus every gene) is present in duplicate. The assay starts with producing a tetraploid cell in which every chromosome exists fourfold. This is done by taking an embryo at the two-cell stage and fusing the two cells by applying an electrical current. The resulting tetraploid cell will continue to divide, and all daughter cells will also be tetraploid.
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/ C6 Y$ T- F- bSuch a tetraploid embryo can develop normally to the blastocyst stage and will implant in the wall of the uterus. The tetraploid cells can form the extra-embryonic tissue (placenta etc.), however a proper fetus will rarely develop.7 @+ D3 |; H+ e3 h/ L
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这是我的理解，请抹了个茶指正。