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the Mesenchymal and Tissue Stem Cell Committee of the International
8 J! C3 k" D! u# \3 @Society for Cellular Therapy proposes minimal criteria to define
: c' T1 h, M- ^7 n! k* M' Nhuman MSC. First, MSC must be plastic-adherent when maintained
$ u$ [7 {; }5 o$ V! C! zin standard culture conditions. Second, MSC must express CD105,
9 i; }' \2 c" Y4 t/ W& n$ p; ~. @/ ~7 ICD73 and CD90, and lack expression of CD45, CD34, CD14 or
. D; W2 t# C- J- C+ u( v$ PCD11b, CD79a or CD19 and HLA-DR surface molecules. Third,
, Q+ C! \% Y& H" `: y. E- zMSC must differentiate to osteoblasts, adipocytes and chondroblasts in5 J% a1 a8 \( Q8 E9 N8 `
vitro. |
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