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# D7 `2 h- C. x# V! W bCOVER Structure of the Wnt signaling molecule (red) in complex with ) C& G3 I; q8 q0 w, O
the Frizzled ligand-binding domain (yellow), schematically depicted as connected
" Y7 {+ ]1 q/ b3 a3 [: A$ Jto the cell surface. A key feature of this structure is the visualization of a
1 A" p K% k/ E- D* ^/ P- w) M9 V1 Rlipid group (blue) on Wnt directly engaging Frizzled. The Wnt/Frizzled mode of + Z& n' @ i' z. c
binding paves the way for the design of Wnt-based therapeutics. See page 59. Image + E6 H7 R, R+ K$ E9 [5 F& V9 x
produced by Eric Smith and Chris Garcia
4 ], ^# ]/ U: f, C1 }$ B, Z5 f[hide][/hide] |
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发表于 2012-7-6 23:39
发表于 2012-7-7 08:53
