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?" M6 W- H) ?, Z% ECOVER Structure of the Wnt signaling molecule (red) in complex with " }5 y$ `& x1 F
the Frizzled ligand-binding domain (yellow), schematically depicted as connected
8 \5 K/ J1 s2 V6 f/ Oto the cell surface. A key feature of this structure is the visualization of a 1 P, A" r9 C) q# f3 Z' z
lipid group (blue) on Wnt directly engaging Frizzled. The Wnt/Frizzled mode of $ ], ]$ r e5 [
binding paves the way for the design of Wnt-based therapeutics. See page 59. Image - B3 Q! r1 D+ Q& P
produced by Eric Smith and Chris Garcia
) h+ w( V/ C6 {& a8 B, a9 z8 M[hide][/hide] |
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发表于 2012-7-6 23:39
发表于 2012-7-7 08:53
