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 & Q; v; l" m* b
COVER Structure of the Wnt signaling molecule (red) in complex with 1 Z- R8 P0 y+ G
the Frizzled ligand-binding domain (yellow), schematically depicted as connected
8 ^# V0 ]# F+ ?1 q9 Hto the cell surface. A key feature of this structure is the visualization of a 5 }7 F0 M/ V, Y
lipid group (blue) on Wnt directly engaging Frizzled. The Wnt/Frizzled mode of
7 ]" C# v3 u! N) J$ Jbinding paves the way for the design of Wnt-based therapeutics. See page 59. Image
; f# R/ R; D U! U4 ?8 c6 gproduced by Eric Smith and Chris Garcia
9 R; `4 a, \$ [# b2 l[hide][/hide] |
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发表于 2012-7-6 23:39
发表于 2012-7-7 08:53
