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RESEARCH HIGHLIGHTS
8 b' d) h* |6 \; B" v5 fGlia: Astrocytes know their place
4 g) ?6 {# U! F6 f4 X8 xNeural development: A fruitless sexual switch
' R: |$ K; ^) u# \& {6 dAxon degeneration: A new pathway emerges4 K% o! o/ y E* J4 i$ J! Y
Techniques: Propriospinal neurons — old but not forgotten
; k% a2 B4 V6 L/ P+ I% H6 aCognitive neuroscience: Adapting to cognitive load- g; F$ g$ j" K
Neuroanatomy: Out with the old (model) ) H& {3 s9 w! J2 |4 U- U. `
Neurodevelopmental disorders: TSCerebellar autism in mice
; y! { z+ z: p4 x( K0 NIN BRIEF
; o4 J# \ l- v, ^) DNeuroimmunology: Harnessing adaptive immunity for AD2 U* k" t2 u+ h: D" y- }; K
Neurological disorders: Focus on miR-134 for seizures
$ ~9 w$ Q4 ?' ]! A8 f3 A `; n' ?- y. {2 TSynaptic physiology: No return for spiking axons: D* S3 \( W' H/ R) w
Neurological disorders: SHANK2 misbehaves in autism, C" K1 F( t! w2 T! G
Glia: Glial AMPA receptors finely tune motor behaviour
8 @4 ^2 b3 D8 q2 U7 xLearning and memory: Listen while you sleep
; \! |3 H# v8 t K# _; | ~Addiction: Targeting nicotine; |; r+ t* n: l* L: D
Sensory systems: The UV regulator
" O6 N+ W* j* f" S/ OPROGRESS
: d+ O' Z, }& T5 I8 G. IControl of central auditory processing by a brain-generated oestrogen7 ^1 v0 v6 ]8 V1 R/ H+ }8 `0 X
Raphael Pinaud & Liisa A. Tremere
0 I7 P1 e3 I% b0 qRecent studies show that oestradiol, the classic female oestrogen, can be locally synthesized by central auditory neurons to rapidly modulate neuronal physiology and auditory-based behaviours in both sexes. Pinaud and Tremere review these findings, which indicate that oestradiol is an important, novel modulator of hearing function.
, q4 ^+ P6 N: }* c" `6 X" pREVIEWS
' n! l5 A( c/ w, p# P! wEmerging roles of non-coding RNAs in brain evolution, development, plasticity and disease
1 ~8 |8 W0 Q% M. M" C! w' b4 V9 sIrfan A. Qureshi & Mark F. Mehler. o/ [. C3 p E! {5 {' S7 _% J
The recent characterization of non-coding RNAs and their astonishingly diverse functions has led to a radical shift in our understanding of how the genome influences neuronal function. In this Review, Qureshi and Mehler describe the numerous classes of non-coding RNAs and how they might contribute to neuronal physiology and disease.
5 q+ X+ ]5 X5 \/ x. J; W( L+ J) h) nCalcium channel auxiliary α2δ and β subunits: trafficking and one step beyond" y Q! Z" N. `
Annette C. Dolphin( P+ L) g% N0 M* S2 h; X% k, h
The α2δ and β subunits of voltage-gated calcium channels (VGCCs) modulate the biophysical properties and trafficking of such channels. In this Review, Annette Dolphin examines the traditional roles of these auxillary subunits and their involvement in neuronal processes that are not linked to VGCC function.
4 M- b0 B2 S8 y' ^; gMultisensory brain mechanisms of bodily self-consciousness
* P$ y T9 F" [9 m1 b' h lOlaf Blanke+ }& I: k1 f/ f5 G
Bodily self-consciousness includes the conscious experience of identifying with the body, of where 'I' am in space, and of the perspective from where 'I' perceive the world. Olaf Blanke discusses the cortical mechanisms that underlie these experiences, highlighting data from neuroimaging, neurology and virtual reality.
; g4 x' B4 c4 N5 X! S) b8 IKnowing how much you don't know: a neural organization of uncertainty estimates8 X- s. m( l' p9 Z$ \* s
Dominik R. Bach & Raymond J. Dolan
# `5 y3 B4 o% u# aDecision making is influenced by uncertainty, which arises from internal and external noise. A fundamental question is how uncertainty is encoded in the brain and how it influences behaviour. In this Review, Bach and Dolan integrate several theoretical concepts about uncertainty into a hierarchical decision-making framework.. y, I# s3 x& `0 i/ g$ \" ^
PERSPECTIVES5 z0 u5 H/ c. ]1 a* e; [
OPINION
" W. A: ~) r4 y7 M- WConcept cells: the building blocks of declarative memory functions Z% {: S c4 j" r# H, A% ~, O
Rodrigo Quian Quiroga
' ]0 E, x2 W/ ~6 ~& t% gNeurons in the human medial temporal lobe respond in a selective and abstract manner to particular persons or objects. Rodrigo Quian Quiroga argues that these 'concept cells' are crucial for memory functions and the transition between related concepts that leads to the flow of consciousness.
% w$ I) R. d; V% N% [) L9 I5 ]0 }" ^Corrigendum: Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair
- p* Z. a! W% w8 wHosung Jung, Byung C. Yoon & Christine E. Holt
% J. H, L4 e* }- ?5 g4 B9 ^1 M0 [7 K7 }! x
Erratum: Will the real multiple sclerosis please stand up?; q! Z3 R) \: z6 v% J. K4 i; t
Peter K. Stys, Gerald W. Zamponi, Jan van Minnen & Jeroen J. G. Geurts4 A0 Z( B% ^; ?7 n
5 F$ r$ R5 p' N! F
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发表于 2012-8-10 23:23
发表于 2012-8-14 08:48
