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RESEARCH HIGHLIGHTS
0 \ t; w7 y2 O* J9 y( n$ VGlia: Astrocytes know their place
3 w g5 `- m7 m8 U% V" ?' PNeural development: A fruitless sexual switch5 ]2 [7 y# B+ j# T% L) v. _, p
Axon degeneration: A new pathway emerges# ~( S5 v+ L2 Q. I
Techniques: Propriospinal neurons — old but not forgotten
; H. v7 Z- b6 ?Cognitive neuroscience: Adapting to cognitive load
9 _9 b: y+ N" z9 ~, JNeuroanatomy: Out with the old (model)
; _; F2 S6 \) }- R6 b7 rNeurodevelopmental disorders: TSCerebellar autism in mice% {. L6 E$ m" z
IN BRIEF
6 U0 T! ^" |! f6 GNeuroimmunology: Harnessing adaptive immunity for AD
7 F8 C- q, G, bNeurological disorders: Focus on miR-134 for seizures $ `% j1 l& j) [+ C* v' U. [1 U( p
Synaptic physiology: No return for spiking axons
- p7 }+ C8 C A( sNeurological disorders: SHANK2 misbehaves in autism' l5 t3 \5 W* I
Glia: Glial AMPA receptors finely tune motor behaviour0 u! J- y% A s7 |: n3 G
Learning and memory: Listen while you sleep
. \7 V. `0 [2 A" S8 b2 yAddiction: Targeting nicotine
- c+ P& ]3 A4 a! U& Y* X9 V9 cSensory systems: The UV regulator, ~* @. X1 _' u
PROGRESS. F8 }" A& D/ Y, P; m* e1 P1 k1 H
Control of central auditory processing by a brain-generated oestrogen( W. C2 r9 ^4 s# ^
Raphael Pinaud & Liisa A. Tremere
- y0 F! m a0 H* d2 U5 MRecent studies show that oestradiol, the classic female oestrogen, can be locally synthesized by central auditory neurons to rapidly modulate neuronal physiology and auditory-based behaviours in both sexes. Pinaud and Tremere review these findings, which indicate that oestradiol is an important, novel modulator of hearing function.
! \- o5 O0 Q; H* L7 X0 {REVIEWS0 [7 U0 W- B' z: O; P6 N: o
Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease( X& D# l; _5 P6 u% u
Irfan A. Qureshi & Mark F. Mehler6 s3 X2 H" O, N% Z- W
The recent characterization of non-coding RNAs and their astonishingly diverse functions has led to a radical shift in our understanding of how the genome influences neuronal function. In this Review, Qureshi and Mehler describe the numerous classes of non-coding RNAs and how they might contribute to neuronal physiology and disease.
/ \; y, F0 V1 x3 h1 qCalcium channel auxiliary α2δ and β subunits: trafficking and one step beyond3 i* `/ N! ?7 L& s- m" e; g
Annette C. Dolphin& E3 l F2 V2 z. T; ?
The α2δ and β subunits of voltage-gated calcium channels (VGCCs) modulate the biophysical properties and trafficking of such channels. In this Review, Annette Dolphin examines the traditional roles of these auxillary subunits and their involvement in neuronal processes that are not linked to VGCC function.
! P$ ^- L' l2 n l; K8 QMultisensory brain mechanisms of bodily self-consciousness
+ L/ T4 v) u& Y3 oOlaf Blanke p$ Q3 p% ~% i$ [
Bodily self-consciousness includes the conscious experience of identifying with the body, of where 'I' am in space, and of the perspective from where 'I' perceive the world. Olaf Blanke discusses the cortical mechanisms that underlie these experiences, highlighting data from neuroimaging, neurology and virtual reality.
' K1 `. I+ J: {+ {Knowing how much you don't know: a neural organization of uncertainty estimates; ] O9 q" ?! z3 A! e& m5 k
Dominik R. Bach & Raymond J. Dolan* o; T# E+ b0 U# ~* p
Decision making is influenced by uncertainty, which arises from internal and external noise. A fundamental question is how uncertainty is encoded in the brain and how it influences behaviour. In this Review, Bach and Dolan integrate several theoretical concepts about uncertainty into a hierarchical decision-making framework.
+ \2 ]# Q7 Q% h7 GPERSPECTIVES, e/ w& g9 y0 X7 h, E1 [/ _3 d1 o
OPINION
, i n z) s7 ~- VConcept cells: the building blocks of declarative memory functions
" a3 X+ M. |( ]+ J& f) M2 bRodrigo Quian Quiroga
- ^+ ^3 ?9 p2 d& d' uNeurons in the human medial temporal lobe respond in a selective and abstract manner to particular persons or objects. Rodrigo Quian Quiroga argues that these 'concept cells' are crucial for memory functions and the transition between related concepts that leads to the flow of consciousness.
' l. u- q! {" Z; Q4 C8 jCorrigendum: Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair
% Y; ?- D8 w+ c/ s9 ?! ~- NHosung Jung, Byung C. Yoon & Christine E. Holt5 y% D. ?( d! m8 y/ X% e
7 t/ g7 V4 n, i6 R/ i( h) f; CErratum: Will the real multiple sclerosis please stand up?
$ ^" M0 q% U) q' R) o$ g, \Peter K. Stys, Gerald W. Zamponi, Jan van Minnen & Jeroen J. G. Geurts1 w. P. M2 g1 B3 K
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发表于 2012-8-10 23:23
发表于 2012-8-14 08:48
