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Comm with me [复制链接]

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发表于 2009-3-6 00:20 |只看该作者 |正序浏览 |打印
Dickson/Elsevier
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& v! [. z( F3 ]Rapid rerouting of intracellular traffic is responsible for the axon guidance of certain fly neurons, according to Krystyna Keleman, Barry Dickson (Research Institute of Molecular Pathology, Vienna, Austria), and colleagues.% {: m) l) y) B  l5 P# b' J

, M  B6 W8 \" T7 fThe neurons do not spend their whole time crossing and recrossing the midline of the fly because the midline repellent Slit binds the Robo receptor. Now, Dickson and colleagues show that crossing events require that the guidance protein Comm grab onto Robo in the Golgi and send it on a suicide journey to late endosomes and lysosomes. This eliminates the influence of Slit, allowing neurons to cross. After crossing, Comm is rapidly turned off to reestablish Robo signaling and prevent recrossing./ U$ a; ]0 n0 c9 `% R3 A
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In the few cases studied, Comm transcription turns on just as neurons initiate their turn toward the midline. This is probably controlled by cell fate determinants that, in turn, are determined by the time and place that the neuron is born. The shutting down of Comm, post-crossing, may be controlled by either a midline-derived signal or a timing mechanism.
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* s3 o# [. a  t2 xComm's activity relies only on a minimal sorting motif, so there may well be Comm-like proteins in mammals. Furthermore, the existence of multiple Comm proteins suggest that these proteins may take many different victims to their deaths. "I guarantee you Comm is doing a lot more than sorting Robo receptors," says Dickson., O2 C& o. a. C6 l) Z

) C/ m* u( p8 d/ q! @: ]Reference:(Midline crossing requires Comm's redirec)

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发表于 2025-5-20 03:59 |只看该作者
拿分走人呵呵,楼下继续!

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发表于 2025-5-5 19:12 |只看该作者
呵呵,支持一下哈  

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发表于 2025-5-2 05:49 |只看该作者
干细胞之家微信公众号
真的有么  

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发表于 2025-4-26 14:09 |只看该作者
顶你一下,好贴要顶!  

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发表于 2025-4-18 07:45 |只看该作者
呵呵 那就好好玩吧~~~~  

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发表于 2025-4-16 05:59 |只看该作者
今天没事来逛逛  

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发表于 2025-4-8 04:57 |只看该作者
初来乍到,请多多关照。。。  

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发表于 2025-4-2 04:27 |只看该作者
感谢党和人民的关爱~~~  

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发表于 2025-3-29 13:18 |只看该作者
顶也~  
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