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Comm with me

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发表于 2009-3-6 00:20 |显示全部帖子
Dickson/Elsevier
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+ A! \# n7 w: [' d3 w/ Z, wRapid rerouting of intracellular traffic is responsible for the axon guidance of certain fly neurons, according to Krystyna Keleman, Barry Dickson (Research Institute of Molecular Pathology, Vienna, Austria), and colleagues./ `" i& H! D# v5 w
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The neurons do not spend their whole time crossing and recrossing the midline of the fly because the midline repellent Slit binds the Robo receptor. Now, Dickson and colleagues show that crossing events require that the guidance protein Comm grab onto Robo in the Golgi and send it on a suicide journey to late endosomes and lysosomes. This eliminates the influence of Slit, allowing neurons to cross. After crossing, Comm is rapidly turned off to reestablish Robo signaling and prevent recrossing.
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$ @  c( c' E$ Z& mIn the few cases studied, Comm transcription turns on just as neurons initiate their turn toward the midline. This is probably controlled by cell fate determinants that, in turn, are determined by the time and place that the neuron is born. The shutting down of Comm, post-crossing, may be controlled by either a midline-derived signal or a timing mechanism.7 L' Q& U, \7 q  F+ L* Q: K
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Comm's activity relies only on a minimal sorting motif, so there may well be Comm-like proteins in mammals. Furthermore, the existence of multiple Comm proteins suggest that these proteins may take many different victims to their deaths. "I guarantee you Comm is doing a lot more than sorting Robo receptors," says Dickson.  O" m+ g: u4 w) j

/ n: W, o- O8 C' c! y% pReference:(Midline crossing requires Comm's redirec)

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发表于 2015-5-27 14:42 |显示全部帖子
淋巴细胞

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发表于 2015-6-10 07:34 |显示全部帖子
干细胞与基因技术

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发表于 2015-6-26 10:27 |显示全部帖子
干细胞之家微信公众号
支持~~  

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发表于 2015-6-26 22:02 |显示全部帖子
文笔流畅,修辞得体,深得魏晋诸朝遗风,更将唐风宋骨发扬得入木三分,能在有生之年看见楼主的这个帖子。实在是我三生之幸啊。  

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发表于 2015-7-19 14:29 |显示全部帖子
只有一条路不能选择——那就是放弃的路;只有一条路不能拒绝——那就是成长的路。  

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发表于 2015-7-21 16:54 |显示全部帖子
哈哈,这么多的人都回了,我敢不回吗?赶快回一个,很好的,我喜欢  

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发表于 2015-9-11 13:18 |显示全部帖子
楼上的稍等啦  

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发表于 2015-9-12 15:52 |显示全部帖子
生殖干细胞

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发表于 2015-10-8 09:09 |显示全部帖子
顶顶更健康,越顶吃的越香。  
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