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2012年11月 Nature Medicine" h+ I, F$ y% e; K5 Y0 w
m3 J, F# {1 x- U/ A) t( jIn this issue, Andrew Weng and his colleagues uncover a new
( ~# l8 ^! w7 I0 x: @ C' Smechanism by which oncogenes regulate leukemia stem cells. Notch-driven 3 @( t: {! q. Y0 g2 K
inactivation of PKCθ attenuates the accumulation of 8 j. Q' W3 D# \( Z" b
reactive oxygen species to lower oxidative stress in the stem cell population of 6 V2 z# s( X, h! N4 W
T cell acute lymphoblastic leukemia (ALL), contributing to tumorigenesis. The & N3 V: j& n7 x
image shows an electron micrograph of erythrocytes and lymphocytes from a 0 `0 l6 ?' h4 F9 ^0 e. ^
patient with ALL. Photo by Steve Gschmeissner/Science Photo Library. # u6 L& C! i' {2 x4 Y
8 i' U+ t$ y) V. E% n! u
$ Z8 X) J+ Y5 D0 i i/ O, e" K6 W1 R; Q1 x/ z( O, W: t
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发表于 2012-11-10 12:55
