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2012年11月 Nature Medicine% e3 H4 o4 u u$ t) z
7 @7 J7 b: T* x) ?4 tIn this issue, Andrew Weng and his colleagues uncover a new ' ^# T o" h( p
mechanism by which oncogenes regulate leukemia stem cells. Notch-driven 6 k3 ?+ n/ j% _7 Y2 C' _' d
inactivation of PKCθ attenuates the accumulation of , u0 @! G j4 m+ q* o
reactive oxygen species to lower oxidative stress in the stem cell population of & A8 n; b; ^4 [4 J* Y1 ^ L
T cell acute lymphoblastic leukemia (ALL), contributing to tumorigenesis. The * F- E( {6 P7 e! v* U
image shows an electron micrograph of erythrocytes and lymphocytes from a
. ^+ t1 @* k4 k. {& npatient with ALL. Photo by Steve Gschmeissner/Science Photo Library. 8 ^' m' h! l, \3 J* N- N+ }' S
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+ r. }( i! H9 v% F# [[hide][/hide] |
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发表于 2012-11-10 12:55
发表于 2012-11-12 16:35
