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2012年11月 Nature Medicine1 V4 d8 h3 D# a$ j. u" W- t) m

3 r' B6 @4 O$ j+ ]8 k; ?5 ?4 bIn this issue, Andrew Weng and his colleagues uncover a new " `. r1 M3 b' x0 t) |
mechanism by which oncogenes regulate leukemia stem cells. Notch-driven 1 H# A) o) D, ~$ G( ^, h% p
inactivation of PKCθ attenuates the accumulation of
% C( f& @8 p5 J' y4 C8 Sreactive oxygen species to lower oxidative stress in the stem cell population of
2 d9 c# z, S$ |# dT cell acute lymphoblastic leukemia (ALL), contributing to tumorigenesis. The
3 i" k* N8 B+ t6 y& X) O2 G; Yimage shows an electron micrograph of erythrocytes and lymphocytes from a , [( J. E. I( Y& ~3 J1 _& j9 `
patient with ALL. Photo by Steve Gschmeissner/Science Photo Library.
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