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2012年11月 Nature Medicine' m' T7 Y' W6 b" o. V# L! N
; A v% @; y+ A2 v, AIn this issue, Andrew Weng and his colleagues uncover a new 3 A6 O V) r+ L' z1 Q% k- N% d9 b5 g# x7 [
mechanism by which oncogenes regulate leukemia stem cells. Notch-driven
0 j9 C- R. b3 G/ {( |4 x0 E; Kinactivation of PKCθ attenuates the accumulation of
; k# F- I" g0 q# a$ m- \reactive oxygen species to lower oxidative stress in the stem cell population of
9 W, l. U' m" l; J( c3 s0 y, Y p- X! aT cell acute lymphoblastic leukemia (ALL), contributing to tumorigenesis. The
" R' u0 P5 d6 |image shows an electron micrograph of erythrocytes and lymphocytes from a 7 K/ k c" @1 v( I* Y7 o) z! A; k: w" N
patient with ALL. Photo by Steve Gschmeissner/Science Photo Library. / @0 C# R( W1 P7 g1 J8 h
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7 M- v7 T2 J# D9 @0 I6 L% K" T[hide][/hide] |
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发表于 2012-11-10 12:55
发表于 2012-11-12 16:35
