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2012年11月 Nature Medicine
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4 {* L* r. b- ~" v/ jIn this issue, Andrew Weng and his colleagues uncover a new
! [: C& y0 p+ E( a# o3 }$ l: Kmechanism by which oncogenes regulate leukemia stem cells. Notch-driven " W' l$ B& g, X' v3 b& t* P
inactivation of PKCθ attenuates the accumulation of
! Z' M2 s/ n5 f8 K8 \- x# b4 K7 {reactive oxygen species to lower oxidative stress in the stem cell population of
: H5 Q1 ^9 k: |6 }( r) ET cell acute lymphoblastic leukemia (ALL), contributing to tumorigenesis. The
V) z. ]& L$ O- H. Q9 Eimage shows an electron micrograph of erythrocytes and lymphocytes from a
* R& Q Y0 e0 w& f3 {, Jpatient with ALL. Photo by Steve Gschmeissner/Science Photo Library. 8 H6 ]7 G. a/ Q4 k( o6 s
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发表于 2012-11-10 12:55
发表于 2012-11-12 16:35
