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Where mtDNA is made [复制链接]

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发表于 2009-3-6 00:45 |只看该作者 |倒序浏览 |打印
On page 503, Meeusen and Nunnari show that yeast mitochondria harbor self-sustaining DNA replication factories.& H0 c" J& _( O

2 z8 r' t/ T9 w0 R& M8 Q, H" i; X; o0 gThe mitochondrial genome (mtDNA) is packaged into nucleoids, some of which attach to the mitochondrial membrane at sites that contain the outer membrane protein Mmm1. Mmm1 binds to the actin cytoskeleton, and mitochondrial movement depends on actin, so one obvious hypothesis is that this DNA–protein structure segregates mtDNA into buds. But Meeusen and Nunnari suggest that Mmm1 and associated proteins replicate, rather than actively segregate, the genome.* X/ ^0 S1 h, k

8 X$ R* D/ ~" OThe authors find that Mmm1-linked nucleoids are associated with both replicating mtDNA and proteins necessary for its duplication, including Mgm101, an essential DNA repair protein, and Mip1, the mtDNA polymerase. These proteins make up an independent structure, spanning two membranes, that is replicated and inherited even in the absence of mtDNA, indicating that the association is not simply a byproduct of DNA-binding abilities. It is not yet clear which components are needed for its replication.
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The structures do not seem to segregate DNA actively, as they had limited movement except in concert with the organelle as a whole. However, they might still ensure faithful mtDNA inheritance by anchoring nucleoids throughout the organelle. This model is consistent with the uniform spacing of the complexes seen in vivo.(A complex of Mgm101 (green) and Mmm1 (re)

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发表于 2015-5-26 10:27 |只看该作者
支持~~  

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藤椅
发表于 2015-5-31 19:25 |只看该作者
观看中  

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板凳
发表于 2015-6-2 09:18 |只看该作者
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我想要`~  

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报纸
发表于 2015-6-7 14:21 |只看该作者
我的啦嘿嘿  

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地板
发表于 2015-6-10 14:26 |只看该作者
顶下再看  

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发表于 2015-6-10 19:16 |只看该作者
我帮你 喝喝  

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发表于 2015-6-11 19:01 |只看该作者
偶啥时才能熬出头啊.  

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发表于 2015-6-12 17:39 |只看该作者
嘿...反了反了,,,,  

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发表于 2015-6-16 10:01 |只看该作者
端粒酶研究
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