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How to renew a stem cell [复制链接]

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发表于 2009-3-6 00:45 |只看该作者 |倒序浏览 |打印
Morrison/Macmillan
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6 W" u& G5 s1 L8 `9 a- H2 S" rThe unique cell cycle characteristics of stem cells are defined, at least in part, by a polycomb transcription factor called Bmi-1, according to Anna Molofsky, Ricardo Pardal, Sean Morrison, and colleagues (University of Michigan, Ann Arbor, MI). Bmi-1 is unique because, unlike other important cell cycle proteins such as Myc, it is needed in stem cells but not in their offspring. Thus, it is important as much for what it is not as for what it is.3 q* R* b2 B6 _- {; ~3 B( R7 a
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The loss of Bmi-1, the researchers find, leaves mice deficient in stem cell capacity. The mice survive using only restricted progenitor cells that are limited in both the types of cells that they can generate and the numbers of divisions in which they can do so. The resulting depletion in cells leads to growth and neurological defects, and early death.
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; V9 {* Q1 w9 [7 h. i3 r8 EEarlier work had established that Bmi-1, via its repression of the cell cycle inhibitor p16, is required for the proliferation of hematopoietic stem cells (HSCs). The Michigan group found a similar phenomenon with stem cells in the central nervous system, at least after birth, and found that the cause was reduced proliferation rather than increased cell death. But after differentiation factors were added, the difference disappeared. Now, both cells with and without Bmi-1 continued to proliferate.2 Z& b  E% v, X: ~% z

& R7 H! W% T* U  ~There are two situations in which an explanation requires more than just Bmi-1 and p16. Prenatally, something other than Bmi-1 must be capable of repressing p16 expression. In the restricted progenitors, meanwhile, Bmi-1 is no longer needed because the cell cycle is now insensitive to elevated levels of p16. Future studies will be focused on understanding this difference in sensitivity, and testing downstream of Bmi-1 for pathways unrelated to p16.
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5 q" U; u7 a* A0 r" _$ }5 hMolofsky, A.V., et al. 2003. Nature. 10.1038/nature02060.(Stem cells lacking Bmi-1 proliferate poo)

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沙发
发表于 2015-6-3 07:54 |只看该作者
…没我说话的余地…飘走  

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藤椅
发表于 2015-6-3 20:53 |只看该作者
每天早上起床都要看一遍“福布斯”富翁排行榜,如果上面没有我的名字,我就去上班……  

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发表于 2015-6-6 17:44 |只看该作者
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ips是诱导多能干细胞induced pluripotent stem cells iPS

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报纸
发表于 2015-6-14 02:54 |只看该作者
几头雾水…  

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地板
发表于 2015-7-8 11:10 |只看该作者
貌似我真的很笨????哎  

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发表于 2015-7-22 09:43 |只看该作者
必须顶  

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发表于 2015-8-4 14:54 |只看该作者
观看中  

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发表于 2015-8-15 11:35 |只看该作者
加油啊!偶一定会追随你左右,偶坚定此贴必然会起到抛砖引玉的作用~  

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发表于 2015-9-1 09:35 |只看该作者
呵呵 那就好好玩吧~~~~  
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