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本帖最后由 细胞海洋 于 2013-4-23 11:11 编辑 - F. t- s$ t; ^5 W7 c* B+ h
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Volume 38, Issue 41 w8 T. E5 F7 M1 E4 z1 P. R
On the cover: The lymphoid stromal microenvironment is required to provide 2 v3 r5 K) G3 O1 }% w
structural support for lymphocyte migration, localization, and function. By fate ' l' h' D3 o1 H5 h/ u* |
mapping analysis, Castagnaro et al. (pages 782–791) show that mature stromal - [" i' P3 O0 n0 o
cells originate from embryonic mesenchymal progenitors of the 0 Q3 ]$ x9 S: p" C' z/ ]& o( A
Nkx2-5+Islet1+ lineage. This study suggests the presence ! E r& Y w; J) Q6 ?
of multipotent progenitors that generate distinct stromal cell subsets and 8 G' Z. G8 H) ^( H
participate in lymphoid tissue remodeling and repair. The cover image depicts a , R) b1 h0 k& {
hierarchical model for generating the stromal microenvironment in development 1 l9 B2 j! u2 @8 g+ T
and organ regeneration whereby the roots represent the stromal progenitors
- u# E' Y5 T2 `, u% I8 o+ [giving rise to fibroblastic reticular cells, follicular dendritic cells, and
; m8 I. f, E# i6 Z$ F- r) k+ r: Gmarginal reticular cells as represented by the leaves. Image by Laura Castagnaro + [+ M/ q7 ?" A; F
and Samir Khadem.
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发表于 2013-4-22 20:01
