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本帖最后由 细胞海洋 于 2013-4-23 11:11 编辑 - W& ]0 z- T' i! D! D% y2 K
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Volume 38, Issue 4
( c5 q& M- l1 t& tOn the cover: The lymphoid stromal microenvironment is required to provide / e8 ? N; \7 @" Y0 H
structural support for lymphocyte migration, localization, and function. By fate % l: P0 [8 p7 P! H5 ^& a
mapping analysis, Castagnaro et al. (pages 782–791) show that mature stromal
, X1 B2 l/ [, Qcells originate from embryonic mesenchymal progenitors of the
& u! a7 v+ U! rNkx2-5+Islet1+ lineage. This study suggests the presence
/ s; T# V- T2 g8 H* yof multipotent progenitors that generate distinct stromal cell subsets and
" ~, M, S, ? j2 o6 h8 R6 X) ]+ sparticipate in lymphoid tissue remodeling and repair. The cover image depicts a 0 j$ D3 J1 {& i: v, S0 D
hierarchical model for generating the stromal microenvironment in development
2 Z! ~1 f) O% v8 J9 M" Zand organ regeneration whereby the roots represent the stromal progenitors
" o; I- w d* j3 e. Agiving rise to fibroblastic reticular cells, follicular dendritic cells, and
, @' J" B4 V8 v" R4 ~3 e" xmarginal reticular cells as represented by the leaves. Image by Laura Castagnaro
1 c! E& x& k3 N! T+ v) ]( c7 N( b$ Yand Samir Khadem.5 j5 F1 d3 e6 m7 _. Y
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发表于 2013-4-22 20:01
