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本帖最后由 细胞海洋 于 2013-4-23 11:11 编辑
# S- {; T! ?# ]; g$ B- D6 _# l3 d
% h* ?- I) E: ^& kVolume 38, Issue 4
4 G9 q9 \, x! e! A; K7 G3 hOn the cover: The lymphoid stromal microenvironment is required to provide N8 i6 f( R* ]' B- T
structural support for lymphocyte migration, localization, and function. By fate
3 Q. ]; O; A4 d: L# tmapping analysis, Castagnaro et al. (pages 782–791) show that mature stromal ; X$ Q) J( i, F' }3 |. b
cells originate from embryonic mesenchymal progenitors of the
% u8 P, x, w9 u9 S- M" XNkx2-5+Islet1+ lineage. This study suggests the presence 5 W) s, g7 X1 O, K9 Z5 y
of multipotent progenitors that generate distinct stromal cell subsets and
$ m" [ c" r0 `6 xparticipate in lymphoid tissue remodeling and repair. The cover image depicts a
9 N# J2 d- t9 \5 s. Khierarchical model for generating the stromal microenvironment in development 9 {3 y$ V1 _6 P
and organ regeneration whereby the roots represent the stromal progenitors
( M' P1 u% i1 M6 agiving rise to fibroblastic reticular cells, follicular dendritic cells, and
, o9 I- ^; [! y0 _( w7 B1 Ymarginal reticular cells as represented by the leaves. Image by Laura Castagnaro / N6 D8 [+ }2 ?+ n, z( _2 R0 v
and Samir Khadem.1 B' D2 c, `$ p7 J- A
. t* g- Z7 N8 q+ B: x, ~
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发表于 2013-4-22 20:01
