《细胞》[Cell]13年4月25日出版pdf全文

nero1981

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Volume 153, Issue 3
- w0 Q# E, S& ~  }( v3 n) COn the cover: DNA methylation (5mC) patterns are established and maintained
, e4 c) k* ]; A& w8 ?1 nby DNA methyltransferases. Removing methyl modifications requires a multistep # u  U- @& M1 @  P) e& j8 l
process. Iterative oxidation of 5mC by TET proteins generates
: Z* \5 }/ A0 c6 _5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine
1 p, U9 ]9 {  h: P# S(5caC). 5fC/5caC can be excised by thymine-DNA glycosylase (TDG) and repaired to 4 R( t& L4 u& _
regenerate unmodified cytosines to complete the methylation and demethylation + y# J* U) c/ a
cycle. In this issue, Shen et al. (pp. 692–706) provide a genome-wide view of
& E+ [. c5 S3 a* n0 f7 P; I+ o% Piterative 5mC oxidation dynamics in mouse embryonic stem cells. Their results 1 h  p! {7 Y: ^% \" a9 Y
indicate that TET/TDG-dependent active DNA demethylation occurs extensively in
4 N4 B( \6 C# x2 e- K! Uthe mammalian genome. In a related paper, Song et al. (pp. 678–691) look at the
6 ~+ X. P' x8 @: z2 c7 t3 m7 Gcontribution of 5mC oxidized states to epigenetic tuning at regulatory elements. 4 ?8 i8 c  w* u
The cyclist on the cover illustrates the cyclic change of cytosine 1 Z% Y3 C5 N) ^/ p
modifications. Artwork by Li Shen and Yi Zhang.
6 {" \1 z- Y3 i  @4 t' f, |9 i[hide][/hide]

懵懂干细胞

辛苦了

yuheng

谢谢

exin11

86964109

谢谢^^

nydfy

thanks

小小元分

kouke80

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vivipet

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tpwang

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: i1 x3 L6 Z+ w* ithanks