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本帖最后由 细胞海洋 于 2013-4-26 21:36 编辑 % d b1 Y6 M2 m. D c$ W
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Volume 153, Issue 30 h9 F" L( d. x/ h# H* k
On the cover: DNA methylation (5mC) patterns are established and maintained , c* H* G( C' Q. H; I
by DNA methyltransferases. Removing methyl modifications requires a multistep 8 {+ b L) a# b7 F- q" R8 _6 H) [
process. Iterative oxidation of 5mC by TET proteins generates
! \ X+ r* P) q3 ?/ l5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine " {: Q% i$ f, V9 |& h
(5caC). 5fC/5caC can be excised by thymine-DNA glycosylase (TDG) and repaired to & n/ Q% h2 G; |9 `2 V, q
regenerate unmodified cytosines to complete the methylation and demethylation 4 y3 \) s& W5 X1 N r* x! B
cycle. In this issue, Shen et al. (pp. 692–706) provide a genome-wide view of
, T" v+ c# M& }iterative 5mC oxidation dynamics in mouse embryonic stem cells. Their results
1 f+ d3 w! D/ o3 B kindicate that TET/TDG-dependent active DNA demethylation occurs extensively in
0 f; ]/ Q. _7 x. M8 b7 A$ mthe mammalian genome. In a related paper, Song et al. (pp. 678–691) look at the
* e9 d$ {! c' q, I* b7 rcontribution of 5mC oxidized states to epigenetic tuning at regulatory elements. . [5 s" X( P8 R" P2 v& Z# v
The cyclist on the cover illustrates the cyclic change of cytosine ) O- K; `) r% L6 m. I
modifications. Artwork by Li Shen and Yi Zhang.* `& A+ c0 P' Q5 v& P# s3 F
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发表于 2013-4-26 20:46
发表于 2013-4-26 21:11
