《细胞》[Cell]13年4月25日出版pdf全文

nero1981

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& R0 C8 ~3 _5 ~8 P& pVolume 153, Issue 39 w9 S% j3 t, s. F& l9 a7 j
On the cover: DNA methylation (5mC) patterns are established and maintained
% I# K1 J3 k& m. d% Rby DNA methyltransferases. Removing methyl modifications requires a multistep
/ a) _2 X4 L/ p- c9 yprocess. Iterative oxidation of 5mC by TET proteins generates 5 I: E+ ~) R/ J  T3 ?: H  j5 m( B
5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine
! E2 V3 ]8 J" s# i' h(5caC). 5fC/5caC can be excised by thymine-DNA glycosylase (TDG) and repaired to
( ^8 z- e+ I  F/ O4 D* oregenerate unmodified cytosines to complete the methylation and demethylation " ?3 W1 g: @5 E0 ^) e/ ]
cycle. In this issue, Shen et al. (pp. 692–706) provide a genome-wide view of 9 z: t/ W' _7 t2 f! L$ [  L
iterative 5mC oxidation dynamics in mouse embryonic stem cells. Their results 0 y: I$ Y3 U2 n5 r% a2 c& w
indicate that TET/TDG-dependent active DNA demethylation occurs extensively in
  c5 c, k! z+ F* \2 Ethe mammalian genome. In a related paper, Song et al. (pp. 678–691) look at the
# l1 ]5 ]. ^8 l7 y) Gcontribution of 5mC oxidized states to epigenetic tuning at regulatory elements. # e( {1 @7 q: }: r6 y
The cyclist on the cover illustrates the cyclic change of cytosine
+ a3 V- x" s8 s6 u, ?3 b- o- umodifications. Artwork by Li Shen and Yi Zhang.
1 C) X" z8 I& U3 j% Y[hide][/hide]

懵懂干细胞

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yuheng

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exin11

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nydfy

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kouke80

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