《细胞》[Cell]13年6月6日出版pdf全文

nero1981

3 [8 l0 z) k& C; V0 [8 N% TVolume 153, Issue 61 Y8 X3 ^9 U9 |2 G* r& I
On the cover: The complementarity determining region 3 of the heavy chain 4 a% O6 D* N1 `! Q" w* _. l& I
(CDR H3) of vertebrate antibodies typically contains a diverse loop of <15 # B& Q  @# W. I$ X
amino acids and often provides a prominent role in binding antigen. Cows have
4 l$ e( h7 H& t, ?& h. W' D! ]& V4 wunusual CDR H3s of >60 amino acids with multiple cysteine residues. How these
! {; D5 ]. N7 X5 R/ R9 aunusual antibodies form and what their structural characteristics are have not
) L: A8 r* ^) ]' j. Mbeen understood. Wang et al. (pp. 1379–1393) show that these antibodies form a
6 E0 |( t6 f# |9 ^, i3 ~, E6 ?new structural domain comprised of “stalk” and “knob” features that are highly ) p% ]. N/ v! _, Z1 M
diverse in amino acid content as well as disulfide patterns. They propose that
* [' Y1 |6 [* B8 jbovine ultralong CDR H3 antibodies create antibody diversity by somatic 0 }' E& |3 t- r/ x6 k4 O
diversification that creates unique disulfide patterns in the knob region. The / ~' ?" t0 f+ I7 L8 d
cover shows the stalk and disulfide-bonded knob of a crystal structure of a cow 8 H4 |2 X7 ]% z  h
antibody (light-green, right) overlaid onto the oil painting “Red Calf Portrait” + m* O; Y8 {. ?7 A$ X4 r$ Y
by Denise Rich.  T: ]' H  |$ r( b9 c

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yuheng

谢谢

exin11

nydfy

THX!

zorro

thanks

懵懂干细胞

感谢楼主分享

ljs

很喜欢这个封面
/ _4 ?1 {- ^% D3 q# b) m

ailingzheng

谢谢楼主

illidancui

xialaikankan

redking2008

很好，下载下来瞧瞧