《细胞》[Cell]13年6月6日出版pdf全文

nero1981

7 ~; o: c! d  H" gVolume 153, Issue 6# Z$ [9 `& `+ [) H: ?6 M9 w1 k0 D/ Z
On the cover: The complementarity determining region 3 of the heavy chain 4 b% }& }& s+ m$ t( M$ A
(CDR H3) of vertebrate antibodies typically contains a diverse loop of <15 & Y( g& f& o& }2 c5 ]
amino acids and often provides a prominent role in binding antigen. Cows have , t: B# l, n- g/ J
unusual CDR H3s of >60 amino acids with multiple cysteine residues. How these
/ t2 j% H- h6 a2 T1 y* }3 Dunusual antibodies form and what their structural characteristics are have not
' z4 Q: ^% N. ubeen understood. Wang et al. (pp. 1379–1393) show that these antibodies form a 6 @& a! t$ ^# c( l6 A
new structural domain comprised of “stalk” and “knob” features that are highly
% v) n& P; H% {7 ~diverse in amino acid content as well as disulfide patterns. They propose that
: P. k5 t$ x& T1 o5 ^3 zbovine ultralong CDR H3 antibodies create antibody diversity by somatic
4 r' ]4 I/ L/ U6 f8 udiversification that creates unique disulfide patterns in the knob region. The
+ A) K! Z, Q; a1 o% K/ I7 {cover shows the stalk and disulfide-bonded knob of a crystal structure of a cow
# _. p+ L7 t( z0 L7 nantibody (light-green, right) overlaid onto the oil painting “Red Calf Portrait” 9 H- i9 U3 i) U: O5 G( p7 ]
by Denise Rich.
5 {2 ~; N; p. Y

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yuheng

谢谢

exin11

nydfy

THX!

zorro

thanks

懵懂干细胞

感谢楼主分享

ljs

很喜欢这个封面
1 X, l4 c" A# J  }% M. x  d

ailingzheng

谢谢楼主

illidancui

xialaikankan

redking2008

很好，下载下来瞧瞧