《细胞》[Cell]13年6月6日出版pdf全文

nero1981

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Volume 153, Issue 65 a$ M. Q' {  S9 w% h* R: W# f) h% ?
On the cover: The complementarity determining region 3 of the heavy chain   N4 R% c3 a! G* w
(CDR H3) of vertebrate antibodies typically contains a diverse loop of <15
- ~4 A0 n) F& k5 H- @0 uamino acids and often provides a prominent role in binding antigen. Cows have
/ f1 X8 \( L$ X0 w3 `unusual CDR H3s of >60 amino acids with multiple cysteine residues. How these
& t$ g2 S* k* B9 xunusual antibodies form and what their structural characteristics are have not   j5 D: @9 T+ Z% @
been understood. Wang et al. (pp. 1379–1393) show that these antibodies form a - H$ U8 P' n) v; m% H( F8 E9 ~
new structural domain comprised of “stalk” and “knob” features that are highly 6 W3 z2 [2 \" O- I- c
diverse in amino acid content as well as disulfide patterns. They propose that
/ {) j4 S, ?5 Zbovine ultralong CDR H3 antibodies create antibody diversity by somatic
1 A* k2 q+ I- t5 _& @diversification that creates unique disulfide patterns in the knob region. The 0 p: s2 ?8 r0 r& b
cover shows the stalk and disulfide-bonded knob of a crystal structure of a cow 5 F$ Y# R( p7 }: v) B/ u+ _: v
antibody (light-green, right) overlaid onto the oil painting “Red Calf Portrait”
3 G4 t5 g" o* h0 {$ ^6 e, Lby Denise Rich.
6 _& b% Q" \9 V2 d

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yuheng

谢谢

exin11

nydfy

THX!

zorro

thanks

懵懂干细胞

感谢楼主分享

ljs

很喜欢这个封面
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ailingzheng

谢谢楼主

illidancui

xialaikankan

redking2008

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