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COVER Intestinal organoids (red) derived in vitro from single
3 E: ^; x' D! Yintestinal stem cells display cryptlike structures with stem and Paneth cells
0 v \. U! h- P(stem cells, green). Infused mini-guts fill in the ulcerated area of an inflamed , u! a0 `4 F2 H2 u- V3 m9 e
colon. Reviews in this special issue on morphogenesis describe recent mini-gut
% f2 s! l/ ^/ J# Y, Dtechnology, as well as advances in light dynamics during development. See the
" ~/ E) S- b Z2 `9 d' F1 zspecial section on page 1183 and at & y0 E" ~+ [" x- ~
www.sciencemag.org/special/morph. " G3 |$ z. o8 t+ K" u$ I
Image: Hans Clevers, Hubrecht Institute
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