|
- 积分
- 17983
- 威望
- 17983
- 包包
- 26159
|
 . m1 X, L/ e! V5 [# o
Volume 21, Issue 67 b% B0 [8 x4 z9 m1 g! Z
On the cover: The modeling of protein structures in the complete absence of ( f ]7 G/ A1 T5 M7 G
any sequential similarity to any known three dimensional structure remains a
2 I. o4 s. B$ G. b3 q8 f# m8 Echallenging problem. Recently, it has been shown that proteins are built from a
" d: t% I6 v+ M% hlimited set of possible supersecondary structural motifs (Smotif). Menon et al.
& C# Z# T% J8 |% \% y0 D7 e(pp. 891–899) provide a hybrid computational algorithm in which NMR chemical
8 }# c7 |4 d& ?7 p0 | ~9 O" yshift information of loop segments is used to guide the selection of entire 5 V: {2 _- K2 r; F1 h0 R- z
Smotifs for any given target sequence. The selected Smotifs then assemble into 1 V, d. I" B% \ s% [# e6 x
three dimensional topology. Although the approach usees only backbone fragments / E ~& |( ~5 N2 ?9 m* n7 Q7 j
of Smotifs without any sequence information and limited experimental " b, P% S* e5 M8 ~' |" g7 k
information, it is successfully capturing the correct topologies of almost all
& a( Q3 g9 ?! F V- N% Atested targets. The cover image was created by Mario Pujato, graduate student at
, }1 _6 j/ d( }& `the Albert Einstein College of Medicine, Bronx, New York.
9 r. Q! V' Z1 O- n! @ d |
-
总评分: 威望 + 20
包包 + 20
查看全部评分
|
发表于 2013-6-10 22:28
