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Volume 21, Issue 6. l8 o5 O! }2 k6 A, a7 \% r) @& ^
On the cover: The modeling of protein structures in the complete absence of
u/ w, n5 ]+ [0 ?% D$ ~2 _any sequential similarity to any known three dimensional structure remains a
) W- X& U* P6 ~+ E( qchallenging problem. Recently, it has been shown that proteins are built from a # i" j, g Y. q; Z9 b& b* |( d1 Q
limited set of possible supersecondary structural motifs (Smotif). Menon et al.
1 ?9 G% @) j& o- S, G, r5 l8 o$ Q(pp. 891–899) provide a hybrid computational algorithm in which NMR chemical
" V3 l; g) k5 x* B e. Eshift information of loop segments is used to guide the selection of entire & O7 ~0 S6 o! x1 S3 Y
Smotifs for any given target sequence. The selected Smotifs then assemble into
* I `3 h: O8 E& g. kthree dimensional topology. Although the approach usees only backbone fragments
# E0 {) l6 x; j& hof Smotifs without any sequence information and limited experimental
s9 w( k) Q8 r; B7 m% ~" R! xinformation, it is successfully capturing the correct topologies of almost all
' \, _8 W, i: |1 O6 z0 x3 Ltested targets. The cover image was created by Mario Pujato, graduate student at ' m! R# ]1 A: p, K3 R. _4 F6 r
the Albert Einstein College of Medicine, Bronx, New York.
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发表于 2013-6-10 22:28
