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 . c6 [6 z E S! W! |6 h% E, A
Volume 21, Issue 6) Z8 E" _! X4 e
On the cover: The modeling of protein structures in the complete absence of 8 d) F% r- `: f( j% Z/ m
any sequential similarity to any known three dimensional structure remains a 1 D9 q; I3 \' c; O3 t6 E8 g3 _) `
challenging problem. Recently, it has been shown that proteins are built from a
! L3 k- m0 `9 N0 Plimited set of possible supersecondary structural motifs (Smotif). Menon et al. . O# q' I! E8 z! N
(pp. 891–899) provide a hybrid computational algorithm in which NMR chemical 2 G& T2 x( H* S' }! }
shift information of loop segments is used to guide the selection of entire 3 r0 W& Q4 o& Z& J
Smotifs for any given target sequence. The selected Smotifs then assemble into
; q) }4 M# B+ u0 a jthree dimensional topology. Although the approach usees only backbone fragments 0 t9 t! c3 X) T# q# f2 k
of Smotifs without any sequence information and limited experimental : J3 _. l" A6 t- L$ V
information, it is successfully capturing the correct topologies of almost all & j5 n/ W+ q% r& J d6 F8 a
tested targets. The cover image was created by Mario Pujato, graduate student at 6 L& P- k: l0 z
the Albert Einstein College of Medicine, Bronx, New York.. g4 U! ~* o3 Y; v' Z
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发表于 2013-6-10 22:28
